Skeleton Pirate

Skeleton Pirate
Artist: LindaB

WELCOME TO STRONTIUM FOR BONES BLOG

Have you experienced, or read about, negative, and even dangerous, side effects from Fosamax (alendronate), Boniva (ibandronate), Actonel (risedronate), and other bisphosphonates prescribed for osteoporosis? If you have, then rest assured there is a safe, effective treatment for this condition. Strontium, primarily in the form of strontium citrate, is taken orally once a day.

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Wednesday, November 27, 2013

Strontium Ranelate and Strontium Citrate Studies


Numerous studies on sr. ranelate found increasing BMD correlated with decreasing fracture risk (references #16 and #21-25 listed at the end of the Comb Study cited below). The French pharmaceutical company, Servier, funded the research on sr. ranelate to market the drug in Europe and elsewhere. Taking a drug through all the required clinical trials takes millions of dollars and the resources of a large company like Servier, which is present in 140 countries, with more than 20,000 employees, including close to 3000 in Research and Development (R&D).

Strontium citrate is not patentable and is sold as a supplement in the U.S. and Canada. There is no monetary incentive for a large pharmaceutical company to do research on strontium citrate. Any research on sr. citrate is most likely to come from universities that have obtained grants. We will continue to see small-scale strontium citrate studies that will add to our knowledge. I do not expect to see large-scale clinical trials involving thousands of subjects taking strontium citrate over a period of several years. Those are the types of trials needed to prove fracture-risk efficacy.  

The following is a review of some significant studies on strontium citrate:

In 2007, two American researchers with SDM College of Dental Sciences in Buffalo, NY, presented their work on osteoblasts at a dental conference. They wrote: “The data support the hypothesis that strontium citrate increases the proliferative/alkaline phosphatase activity of human osteoblastic cells from alveolar bone. The results validate previous research that has been done with other forms of strontium in clinical studies and rodent calvarial cells and indicates that strontium citrate could be a promising agent in treating oral as well as systemic bone disorders.”  The abstract of their paper is available here: http://iadr.confex.com/iadr/2007orleans/techprogram/abstract_89231.htm

 In 2012, two Canadian researchers, one with the University of Alberta, the other with the University of Calgary, published the results of a one-year study called the Combination of Micronutrients for Bone (COMB) Study. The daily protocol consisted of: docosahexanoic acid or DHA (from Purified Fish Oil) 250 mg, vitamin D3 2000 IU, vitamin K2 (non-synthetic MK7 form) 100 ug, Strontium citrate 680 mg elemental strontium, and elemental magnesium 25 mg/day. Dietary sources of calcium were recommended. Daily impact exercising was encouraged. The researchers concluded: This combined micronutrient supplementation regimen appears to be at least as effective as bisphosphonates or strontium ranelate in raising BMD levels in hip, spine, and femoral neck sites. No fractures occurred in the group taking the micronutrient protocol. This micronutrient regimen also appears to show efficacy in individuals for whom bisphosphonate therapy was previously unsuccessful in maintaining or raising BMD. Prospective clinical trials are required to confirm efficacy.” The complete article is available here: http://www.hindawi.com/journals/jeph/2012/354151/
In July, 2012, four researchers at Ryerson University in Toronto, Canada, published a study in “Bone” entitled: “Monitoring bone strontium levels of an osteoporotic subject due to self-administration of strontium citrate with a novel diagnostic tool, in vivo XRF: a case study.” This study is significant because it used a non-invasive method (not an invasive method, such as bone biopsy) to analyze the strontium levels of bones in an osteoporotic patient who began taking strontium citrate for the study. Therefore, it was possible to obtain her baseline bone strontium levels prior to initiation of therapy with strontium citrate. The researchers wrote: “By 120 hours, the increase (in bone strontium level) was statistically significant at 0.68 ± 0.07 and 0.93 ± 0.05 (for the finger and ankle), respectively. Further increases occurred within an interval of 90-180 days, with the most recent, after 800 days, at the finger and ankle being 7 and 15 times higher than the initial baseline reading. The intriguing results show bone strontium incorporation and retention follow a pattern, suggesting strontium levels, at least in the ankle, do not plateau within two to three years and will continue to increase over time, as an individual takes strontium supplements. The ability of this IVXRF (in vivo X-ray fluorescence) system to monitor and measure bone strontium levels over time provides a useful diagnostic tool to help gain insight into strontium bone kinetics.” The abstract can be read here:  http://www.ncbi.nlm.nih.gov/pubmed/22549020

4 comments:

LadyPicker said...

Wow! I am so excited to find your blog. It is so comforting to know there are others like me out there who are researching and using strontium for their osteoporosis. I was diagnosed at aged 40 (secondary osteoporosis as a result of medication and an early hysterectomy). I have never taken any of the traditional medications as the initial foo ax and actonel gave me reflux. I always had a bad vibe about being so young and being on these meds.

I have a tendency to get spontaneous rib fractures...had two this summer and currently have a stress fracture of a metatarsal bone. I began taking strontium several months ago but only recently found out I could take the higher dose 680mg. I supplement with plant based calcium, high dose of vitamin D3, k1/k2 pill, magnesium (amino acid chelate). My doctor doesn't argue with me because I think she knows the traditional meds aren't that great.

I wish there was a private Facebook group dedicated to us folks. Have you thought of starting one? I would be willing to start it or help as an admin. Again, I can't tell you how good it is to connect with others of like mind! Thank you for all you do with your blog.
Marge

BoneLady said...

LadyPicker,

Thank you for your comments. I hope the strontium and other supplements stop future fractures for you.

This blog has a link on facebook. You can post questions or comments on my blog or on my facebook page at http://www.facebook.com/?sk=welcome#!/pages/Strontium-for-Osteoporosis/462179087156676.

BoneLady

Anonymous said...

I started on strontium Dec 14, 2013. Within one week, I was having soreness in one hip joint. I continued with it until Dec 31, with the joint soreness continuing. I stopped taking strontium on Jan 1, 2014 and tonight, Jan 2, I have no soreness. I have read of people having wrist pain as a side effect of strontium. I will remain off it for another day and then resume taking just one capsule/day and see what that does. I am -2.2 bone density in hips and spine. I will try to find your facebook page.

BoneLady said...

According to Servier, the maker of strontium ranelate, there have been post-marketing reports of
musculoskeletal pain (muscle spasm, myalgia, bone pain, arthralgia and pain in extremity), but the frequency is unknown. You didn’t say what type of strontium you are taking. I think you have the right idea about discontinuing treatment with strontium for a while and then resuming it, but you should wait at least two weeks to perhaps a month before resuming treatment. When you do start taking strontium again, beginning with a half dose of 340 mg and then, after a month or more, increasing the dosage if you are tolerating it, is also a good idea. Also, note how much calcium and vitamin D you are taking. You should have your serum calcium and vitamin D levels tested if you have not done so recently. I wish you progress with your treatment and good health in the New Year.

Wandering Skeleton

Wandering Skeleton
Artist: Joel Hoekstra

Osteoporotic Bone

Osteoporotic Bone
Source: www.mayoclinic.com

How Strontium Builds Bones

Strontium is a mineral that tends to accumulate in bone. Studies have shown that oral doses of strontium are a safe and effective way to prevent and reverse osteoporosis. Doses of 680 mg per day appear to be optimal. See my "For More Information About Strontium" links section.

Osteoporosis is caused by changes in bone production. In healthy young bones there is a constant cycle of new bone growth and bone removal. With age, more bone is removed and less new bone is produced. The bones become less dense and thus more fragile.

Scientists believe that strontium works in two ways. It may stimulate the replication of pre-osteoblasts, leading to an increase in osteoblasts (cells that build bone). Strontium also directly inhibits the activity of osteoclasts (cells that break down bone). The result is stronger bones.

When taking strontium, be sure to take 1200 mg calcium, 1000 IU vitamin D3, and 500 mg magnesium daily. It is best to take strontium late at night on an empty stomach. Calcium and strontium may compete with each other for absorption if taken together.