Skeleton Pirate

Skeleton Pirate
Artist: LindaB


Have you experienced, or read about, negative, and even dangerous, side effects from Fosamax (alendronate), Boniva (ibandronate), Actonel (risedronate), and other bisphosphonates prescribed for osteoporosis? If you have, then rest assured there is a safe, effective treatment for this condition. Strontium, primarily in the form of strontium citrate, is taken orally once a day.

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Monday, April 29, 2013

EMA Confirms Recommendations to Restrict Strontium Ranelate

The European Medicines Agency (EMA) has confirmed the recommendations to restrict the use of strontium ranelate (Protelos/Osseor, Servier) due to concerns about the risk of adverse cardiac events. The EMA's Pharmacovigilance Risk Assessment Committee (PRAC) recommended the restrictions earlier this month, and the Committee for Medicinal Products for Human Use (CHMP) has now endorsed these following its meeting of April 22-25, 2013. The CHMP opinion will be sent to the European Commission, the executive branch of the European Union, which will issue a legally binding decision.

Tuesday, April 23, 2013

Strontium and Your Heart

A committee of the European Medicines Agency (EMA) has recommended the following restrictions in the use of strontium ranelate (sold in the European Union under the brand names Protelos and Osseor) to reduce the risk of adverse cardiac events:

1a. Strontium ranelate should only be used for the treatment of severe osteoporosis in postmenopausal women at high risk for fracture and severe osteoporosis in men at increased risk for fracture.

2a.Strontium ranelate should not be used in patients with current or past history of ischemic heart disease (such as angina or MI), peripheral arterial disease (PAD), or cerebrovascular disease.

3a.Strontium ranelate should not be used in patients with hypertension that is not controlled by treatment.

What, if anything, should those of us taking strontium citrate do?

Here is what I think.

1b. Strontium citrate can be used as a supplement by men and women with osteopenia or osteoporosis. (I believe the first restriction on strontium ranelate is mostly for cost containment because bisphosphonates, especially the generic equivalents, are much cheaper than strontium ranelate.) 

2b. Strontium citrate can be used UNDER MEDICAL SUPERVISION in patients with current or past history of ischemic heart disease, PAD, or cerebrovascular disease.

    3b. Strontium citrate should not be used in patients with uncontrolled hypertension. Patients must get their hypertension under control by medication. Strontium citrate can be used UNDER MEDICAL SUPERVISION in patients with hypertension that is controlled by treatment.

Wandering Skeleton

Wandering Skeleton
Artist: Joel Hoekstra

Osteoporotic Bone

Osteoporotic Bone

How Strontium Builds Bones

Strontium is a mineral that tends to accumulate in bone. Studies have shown that oral doses of strontium are a safe and effective way to prevent and reverse osteoporosis. Doses of 680 mg per day appear to be optimal. See my "For More Information About Strontium" links section.

Osteoporosis is caused by changes in bone production. In healthy young bones there is a constant cycle of new bone growth and bone removal. With age, more bone is removed and less new bone is produced. The bones become less dense and thus more fragile.

Scientists believe that strontium works in two ways. It may stimulate the replication of pre-osteoblasts, leading to an increase in osteoblasts (cells that build bone). Strontium also directly inhibits the activity of osteoclasts (cells that break down bone). The result is stronger bones.

When taking strontium, be sure to take 1200 mg calcium, 1000 IU vitamin D3, and 500 mg magnesium daily. It is best to take strontium late at night on an empty stomach. Calcium and strontium may compete with each other for absorption if taken together.