Skeleton Pirate

Skeleton Pirate
Artist: LindaB

WELCOME TO STRONTIUM FOR BONES BLOG

Have you experienced, or read about, negative, and even dangerous, side effects from Fosamax (alendronate), Boniva (ibandronate), Actonel (risedronate), and other bisphosphonates prescribed for osteoporosis? If you have, then rest assured there is a safe, effective treatment for this condition. Strontium, primarily in the form of strontium citrate, is taken orally once a day.

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Blog Archive

Monday, April 17, 2017

Strontium Ranelate Withdrawal from European Countries



Cessation of marketing of Protelos/Osseor: Extract of the letter sent to European Medicine Agency (EMA) and national European Agencies on 10 February 2017

14/03/2017

Similar letters, adapted to local regulations, have been sent to all countries worldwide where Protelos/Osseor® is marketed

PROTELOS/OSSEOR® - Cessation of marketing

On 21 September 2004, Protelos/Osseor® (strontium ranelate), centrally authorised medicinal product, was granted a Marketing Authorisation by the European Commission for the European Union (EU).

Protelos/Osseor® is indicated in the treatment of severe osteoporosis in postmenopausal women and in adult men at high risk of fracture, for whom treatment with other medicinal products approved for the treatment of osteoporosis is not possible due to, for example, contraindications or intolerance.

Les Laboratoires Servier hereby notify the cease of the marketing, permanently, in the European countries where it is currently marketed.
This worldwide and strategic decision is taken for commercial reasons based on the following grounds:
  • The restricted indication/limited use of Protelos/Osseor®,
  • The continuous decrease of patients treated with Protelos/Osseor®.
Les Laboratoires Servier will cease the distribution of Protelos/Osseor® in August 2017.
Servier, founded in 1954, is the first independent pharmaceutical group. We are present in 140 countries, with more than 21 000 employees, including close to 3000 in R&D.


My note: Those who will no longer be prescribed strontium ranelate can buy nonprescription strontium citrate. 

Tuesday, February 14, 2017

MOTS and COMB Study Comparison



A one-year study on strontium citrate combined with melatonin and other supplements and named the Melatonin-micronutrients Osteopenia Treatment Study (MOTS) was recently published (January 26, 2017). I’d like to compare it to the Combination of Micronutrients for Bone (COMB) Study published in 2012. See the following chart:
        
    COMB Study                                                               MOTS

Study size                        114                                                                                  20
Baseline BMD status      osteoporosis                                                                   osteopenia
Strontium (citrate)               680 mg                                                                          450 mg
Vitamin K2 (MK7)               100 mcg                                                                         60 mcg
Melatonin                              none                                                                                5 mg                        
Vitamin D3                         2000 IU                                                                          2000 IU
Docosahexanoic acid (DHA)   250 mg                                                                      none
Magnesium                             25 mg                                                                          none
Lumbar spine BMD             6% increase                                                             4.3% increase
Femoral neck BMD             4% increase                                                             2.2% increase
Total hip BMD               3% increase                                                             No sign. diff., pos. trend

I could have predicted the results on BMD. How? Well, it had previously been shown, from studies on strontium ranelate, that strontium increased BMD at all dosages studied, but the optimum increases were gained with 680 mg strontium. Also, melatonin has been used for years as a sleep aid, but there is little evidence for it as a bone supplement. The authors of MOTS named two studies on melatonin listed below.         

“Limitations to this study include low number of subjects, lack of a diverse cohort and lack of different micronutrient combinations on primary and secondary endpoints in MOTS clinical trial.”

Despite the limitations of MOTS, there is valuable information to be gained from it:

MOTS increased awareness of the importance of preventative care in patients with osteopenia. “Over half of all women in the U.S. above age 50 have osteopenia with a prevalence of approximately 3.4 times more than osteoporosis. Consequently, twice the number of fractures arises from women with osteopenia as they represent almost 50% of the total population at risk.”

“The 10-year vertebral fracture risk probability decreased by 6.48% in response to MSDK (melatonin, strontium, vitamins D and K) therapy compared to 10.8% increase in placebo.”

“MSDK reduced bone marker turnover primarily by increasing the bone formation marker P1NP and maintaining healthy bone turnover.”

“MSDK demonstrated positive effects on inflammatory status and improved quality of life especially related to sleep.”

MOTS confirmed that dosages lower than 680 mg strontium will increase BMD by lower percentages.
                       



Kotlarczyk MP, Lassila HC, O’Neil CK, D’Amico F, Enderby LT, WittEnderby PA, Balk JL. Melatonin osteoporosis prevention study (MOPS): a randomized, doubleblind, placebocontrolled study examining the effects of melatonin on bone health and quality of life in perimenopausal women. J Pineal Res. 2012; 52:414–26. doi: 10.1111/j.1600079X.2011.00956.x

Amstrup AK, Sikjaer T, Heickendorff L, Mosekilde L, Rejnmark L. Melatonin improves bone mineral density at the femoral neck in postmenopausal women with osteopenia: a randomized controlled trial. J Pineal Res. 2015; 59:221–29. doi:10.1111/jpi.12252

Wednesday, December 21, 2016

My Daily Supplements Update



I take one of each supplement daily, except for strontium. I take two capsules of strontium per day.

  1. Bluebonnet Lecithin, 1365 mg in one softgel
  2. Solgar Citrus Bioflavonoid Complex, 1000 mg per tablet
  3. Country Life, Gluten Free, Calcium Magnesium Complex (500 mg Ca, 250 mg Mg per tablet)
  4. Doctor’s Best Lutein with Optilut, 20 mg lutein esters yielding 10 mg minimum of free lutein, 2 mg zeaxanthin per capsule
  5. AOR Strontium Support II, 341 mg strontium (from citrate) per capsule (two capsules daily)
  6. Nature Made Multi for Him, No Iron (Not a typo. My husband and I both take this multivitamin.)
  7. Nature Made Vitamin C, 500 mg
  8. Solgar Natural Vitamin E (as d-Alpha Tocopherol plus d-Beta, d-Delta and d-Gamma Tocopherols), 400 IU
  9. Nature’s Way Primadophilus bifidus (This is a probiotic.)
10. Solgar Sublingual Methylcobalamin, 5000 mcg
11. Solgar Zinc (as zinc gluconate), 50 mg

I have made a few changes since my last daily supplements update on June 11, 2015:

http://strontiumforbones.blogspot.com/2015/06/my-daily-supplements.html

The most significant change was the switch from Doctor’s Best Strontium Bone Maker to AOR Strontium Support II. I made this change after Doctor’s Best was sold to a Chinese company and before discovering that Doctor's Best Strontium was discontinued in July 2016 (60- and 120-count bottles) and September 2016 (360-count bottle).  

I reduced my dosage of Bluebonnet Lecithin from two to one softgel, which is a serving per the label. Many years earlier, I had been taking three softgels per day. The reason for my latest dosage reduction is that there is currently some controversy about the health benefits of lecithin. I’ve been taking it for many years for cardiovascular health.

https://en.wikipedia.org/wiki/Lecithin  See the introduction and the section on “Biology” in Wikipedia for an overview of lecithin, choline, and phospholipids, such as phosphatidylcholines, a class of phospholipids that incorporate choline as a head group.  

https://www.ncbi.nlm.nih.gov/pubmed/26108618  “Effects of choline on health across the life course: a systematic review.”

I also switched from Nature’s Bounty Vitamin E to Solgar Vitamin E, from Twin Labs Zinc to Solgar Zinc, and from Country Life Citrus Bioflavonoids and Rutin to Solgar Citrus Bioflavonoid Complex. These changes were due solely to unavailability at my online supplement distributor, iherb.com, which no longer stocks Nature’s Bounty Vitamin E or Twin Labs Zinc. Country Life Citrus Bioflavonoids and Rutin is out of stock at iherb.com until 12/25/2016. I may buy whichever bioflavonoid brand is available when I reorder.

I like my supplier’s next day air expedited shipping (at extra cost) because some vitamins and supplements are heat labile. I am unhappy with its current policy of giving a discount, based on total amount of current invoice, for my NEXT purchase rather than for my CURRENT purchase, as was previously done. This policy has raised my costs. 


Monday, September 26, 2016

Doctor's Best Has Been Sold to a Chinese Company



On June 15, 2016, North Castle Partners and its co-investors announced the sale of Doctor's Best, Inc. ("Doctor's Best" or "DRB"), a leading marketer and distributor of branded nutritional supplements (e.g., Doctor's Best Strontium Bone Maker brand of strontium citrate), to Xiamen Kingdomway Group Co. (SHE: 002626). For North Castle Partners, the exit concludes another successful partnership in the nutritional supplements industry. The terms of the transaction were not disclosed.

About North Castle Partners
North Castle Partners is a private equity firm focused on investments in product and service businesses that promote healthy, active, and sustainable living. North Castle is a hands-on, value-added investor in high-growth, middle market companies in the (i) beauty and personal care, (ii) consumer health, (iii) fitness, recreation and sports, (iv) home and leisure and (v) nutrition sectors, among others. North Castle's current portfolio includes such well-known brands as Curves International/Jenny Craig, Barry's Bootcamp, Palladio Beauty Group, Mineral Fusion, Red Door Spas, Sprout Organics, SmartyPants, Brooklyn Boulders, Ibex Outdoor Clothing, and Turnbridge. North Castle is headquartered in Greenwich, CT. For more information, visit www.northcastlepartners.com.

About Doctor's Best, Inc.
Irvine, CA-based Doctor's Best, Inc. manufactures and distributes dietary supplements.  Doctor's Best is known for a broad line of products based on sound research and manufactured with quality ingredients. For more information, visit www.drbvitamins.com.

About Xiamen Kingdomway Group Co.
Xiamen Kingdomway Group Company (KDW) was founded in 1997 as a key High-tech Enterprise of the National Torch Project and was publicly listed on the Shenzhen Stock Exchange in 2011 under the ticker 002626. With over 1,500 employees, KDW is one of the first high-tech enterprises in Xiamen, China.  KDW is a fully integrated global nutrition company. KDW currently provides Coenzyme Q10, Microalgea DHA, ARA, Vitamin A, Vitamin D3 and Beta-Carotene, with many more products in a well-established research and development process. KDW has retail stores in Singapore, sales outlets throughout Southeast Asia, a joint venture in Japan and wholly owned subsidiaries in the United States, including Vit-Best Nutrition, a contract manufacturer of nutritional supplements and, with this most recent acquisition, Doctor's Best. 

Wandering Skeleton

Wandering Skeleton
Artist: Joel Hoekstra

Osteoporotic Bone

Osteoporotic Bone
Source: www.mayoclinic.com

How Strontium Builds Bones

Strontium is a mineral that tends to accumulate in bone. Studies have shown that oral doses of strontium are a safe and effective way to prevent and reverse osteoporosis. Doses of 680 mg per day appear to be optimal. See my "For More Information About Strontium" links section.

Osteoporosis is caused by changes in bone production. In healthy young bones there is a constant cycle of new bone growth and bone removal. With age, more bone is removed and less new bone is produced. The bones become less dense and thus more fragile.

Scientists believe that strontium works in two ways. It may stimulate the replication of pre-osteoblasts, leading to an increase in osteoblasts (cells that build bone). Strontium also directly inhibits the activity of osteoclasts (cells that break down bone). The result is stronger bones.

When taking strontium, be sure to take 1200 mg calcium, 1000 IU vitamin D3, and 500 mg magnesium daily. It is best to take strontium late at night on an empty stomach. Calcium and strontium may compete with each other for absorption if taken together.