Skeleton Pirate

Skeleton Pirate
Artist: LindaB

WELCOME TO STRONTIUM FOR BONES BLOG

Have you experienced, or read about, negative, and even dangerous, side effects from Fosamax (alendronate), Boniva (ibandronate), Actonel (risedronate), and other bisphosphonates prescribed for osteoporosis? If you have, then rest assured there is a safe, effective treatment for this condition. Strontium, primarily in the form of strontium citrate, is taken orally once a day.

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Blog Archive

Sunday, November 12, 2017

Strontium and Calcium and Vitamin D



Anyone concerned with bone health, whether taking strontium or not, should have an adequate daily intake of calcium from food or supplements or a combination of the two. In other words, if an individual can get all her calcium from food, she does not need to supplement. However, most people probably will need some calcium supplementation.

The risks of inadequate intake of calcium and vitamin D are reduced calcium absorption, increased serum parathyroid hormone (PTH) concentrations, and bone loss. Low bone mass is a strong predictor of fracture.

There is a rationale for supplementing the diets of elderly subjects with a combination of calcium and vitamin D. Absorption of calcium and possibly of vitamin D and production of vitamin D by the skin decline with aging. Diets deficient in calcium tend also to be deficient in vitamin D because a single food, milk, is the principal dietary source of both these nutrients.


There is no clinical study of strontium with inadequate calcium and vitamin D because such a study would violate the ethical medical standard of doing no harm to patients.

Before inclusion in the TROPOS study of strontium ranelate, patients were subjected to a run-in study to initiate normalization of their calcium and vitamin D status. The duration of this run-in study was 2 wk to 6 months, depending on the severity of calcium and 25-OH vitamin D (25-OH D) deficiency. All enrolled women received daily supplements of up to 1000 mg of elemental calcium adapted to their needs according to their dietary intake (0, 500, or 1000 mg to reach a total daily intake above 1000 mg), and vitamin D according to their serum 25-OH D levels (800 IU for patients having serum 25-OH D lower than 45 nmol/liter and 400 IU for all the others). For patients with severe vitamin D deficiency (25-OH D lower than 30 nmol/liter) the duration of the run-in period was at least 3 months.
 
https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.2004-1774

Thursday, October 12, 2017

Combined Strontium and Vitamin D Therapy for Osteoporosis

The following abstract is for a clinical study titled "Correction of Vitamin D Insufficiency with Combined Strontium Ranelate and Vitamin D3 in Osteoporotic Patients" by R. Rizzoli et al. It was made available online 9 December 2013. Please note that I have converted the 25-hydroxyvitamin D units from nmol/l to ng/mL (1 ng/mL = 2.5 nmol/L) and added those units in parentheses. My personal daily osteoporosis therapy includes 2 grams strontium citrate (680 mg strontium) and 1000 IU vitamin D (included in my Nature Made Multi for Him multivitamin).

Objective This study aims to investigate the efficacy and safety of oral fixed-dose combination of strontium ranelate 2 g/vitamin D3 1000 IU daily vs strontium ranelate 2 g daily for correcting vitamin D insufficiency in osteoporosis.

Design A 6-month international, randomized, double-blind, parallel-group, phase 3 study.

Methods A total of 518 men and postmenopausal women aged greater than or equal to 50 years with primary osteoporosis (T-score less than or equal to −2.5 s.d.) and serum 25-hydroxyvitamin D (25(OH)D)greater than 22.5 nmol/l (9 ng/mL) were included. Patients were allocated to strontium ranelate 2 g/vitamin D3 1000 IU daily (n=413) or strontium ranelate 2 g daily (n=105). The participants received calcium 1 g daily. The primary endpoint was serum 25(OH)D at last post-baseline evaluation during 3 months.

Results Both groups were comparable at baseline. Mean baseline of 25(OH)D was 44.1 plus or minus 14.6 nmol/l (17.6 ng/mL plus or minus 5.8 ng/mL). After 3 months, the percentage of patients with 25(OH)D greater than or equal to 50 nmol/l (20 ng/mL) was higher with strontium ranelate/vitamin D3 vs strontium ranelate (84 vs 44%, P less than 0.001; adjusted between-group odds ratio=6.7; 95% CI, 4.2–10.9). The efficacy of the fixed-dose combination on 25(OH)D was maintained at 6 months (86 vs 40%, P less than 0.001). Mean 25(OH)D was 65.1nmol/l (26 ng/mL) and 49.5 nmol/l (19.8 ng/mL), respectively, after 3 months and 66.9 nmol/l (26.8 ng/mL) and 45.4 nmol/l (18.2 ng/mL) after 6 months. Physical performance improved in both groups. Falls were 17 and 20% in the strontium ranelate/vitamin D3 and strontium ranelate groups respectively. Parathyroid hormone levels were inversely correlated with 25(OH)D. No clinically relevant differences in safety were observed.

Conclusions This study confirms the efficacy and safety of fixed-dose combination of strontium ranelate 2 g/vitamin D3 1000 IU for correction of vitamin D insufficiency in osteoporotic patients. 

http://www.eje-online.org/content/170/3/441.short

Monday, April 17, 2017

Strontium Ranelate Withdrawal from European Countries



Cessation of marketing of Protelos/Osseor: Extract of the letter sent to European Medicine Agency (EMA) and national European Agencies on 10 February 2017

14/03/2017

Similar letters, adapted to local regulations, have been sent to all countries worldwide where Protelos/Osseor® is marketed

PROTELOS/OSSEOR® - Cessation of marketing

On 21 September 2004, Protelos/Osseor® (strontium ranelate), centrally authorised medicinal product, was granted a Marketing Authorisation by the European Commission for the European Union (EU).

Protelos/Osseor® is indicated in the treatment of severe osteoporosis in postmenopausal women and in adult men at high risk of fracture, for whom treatment with other medicinal products approved for the treatment of osteoporosis is not possible due to, for example, contraindications or intolerance.

Les Laboratoires Servier hereby notify the cease of the marketing, permanently, in the European countries where it is currently marketed.
This worldwide and strategic decision is taken for commercial reasons based on the following grounds:
  • The restricted indication/limited use of Protelos/Osseor®,
  • The continuous decrease of patients treated with Protelos/Osseor®.
Les Laboratoires Servier will cease the distribution of Protelos/Osseor® in August 2017.
Servier, founded in 1954, is the first independent pharmaceutical group. We are present in 140 countries, with more than 21 000 employees, including close to 3000 in R&D.


My note: Those who will no longer be prescribed strontium ranelate can buy nonprescription strontium citrate. 

Tuesday, February 14, 2017

MOTS and COMB Study Comparison



A one-year study on strontium citrate combined with melatonin and other supplements and named the Melatonin-micronutrients Osteopenia Treatment Study (MOTS) was recently published (January 26, 2017). I’d like to compare it to the Combination of Micronutrients for Bone (COMB) Study published in 2012. See the following chart:
        
    COMB Study                                                               MOTS

Study size                        114                                                                                  20
Baseline BMD status      osteoporosis                                                                   osteopenia
Strontium (citrate)               680 mg                                                                          450 mg
Vitamin K2 (MK7)               100 mcg                                                                         60 mcg
Melatonin                              none                                                                                5 mg                        
Vitamin D3                         2000 IU                                                                          2000 IU
Docosahexanoic acid (DHA)   250 mg                                                                      none
Magnesium                             25 mg                                                                          none
Lumbar spine BMD             6% increase                                                             4.3% increase
Femoral neck BMD             4% increase                                                             2.2% increase
Total hip BMD               3% increase                                                             No sign. diff., pos. trend

I could have predicted the results on BMD. How? Well, it had previously been shown, from studies on strontium ranelate, that strontium increased BMD at all dosages studied, but the optimum increases were gained with 680 mg strontium. Also, melatonin has been used for years as a sleep aid, but there is little evidence for it as a bone supplement. The authors of MOTS named two studies on melatonin listed below.         

“Limitations to this study include low number of subjects, lack of a diverse cohort and lack of different micronutrient combinations on primary and secondary endpoints in MOTS clinical trial.”

Despite the limitations of MOTS, there is valuable information to be gained from it:

MOTS increased awareness of the importance of preventative care in patients with osteopenia. “Over half of all women in the U.S. above age 50 have osteopenia with a prevalence of approximately 3.4 times more than osteoporosis. Consequently, twice the number of fractures arises from women with osteopenia as they represent almost 50% of the total population at risk.”

“The 10-year vertebral fracture risk probability decreased by 6.48% in response to MSDK (melatonin, strontium, vitamins D and K) therapy compared to 10.8% increase in placebo.”

“MSDK reduced bone marker turnover primarily by increasing the bone formation marker P1NP and maintaining healthy bone turnover.”

“MSDK demonstrated positive effects on inflammatory status and improved quality of life especially related to sleep.”

MOTS confirmed that dosages lower than 680 mg strontium will increase BMD by lower percentages.
                       



Kotlarczyk MP, Lassila HC, O’Neil CK, D’Amico F, Enderby LT, WittEnderby PA, Balk JL. Melatonin osteoporosis prevention study (MOPS): a randomized, doubleblind, placebocontrolled study examining the effects of melatonin on bone health and quality of life in perimenopausal women. J Pineal Res. 2012; 52:414–26. doi: 10.1111/j.1600079X.2011.00956.x

Amstrup AK, Sikjaer T, Heickendorff L, Mosekilde L, Rejnmark L. Melatonin improves bone mineral density at the femoral neck in postmenopausal women with osteopenia: a randomized controlled trial. J Pineal Res. 2015; 59:221–29. doi:10.1111/jpi.12252

Wednesday, December 21, 2016

My Daily Supplements Update



I take one of each supplement daily, except for strontium. I take two capsules of strontium per day.

  1. Bluebonnet Lecithin, 1365 mg in one softgel
  2. Solgar Citrus Bioflavonoid Complex, 1000 mg per tablet
  3. Country Life, Gluten Free, Calcium Magnesium Complex (500 mg Ca, 250 mg Mg per tablet)
  4. Doctor’s Best Lutein with Optilut, 20 mg lutein esters yielding 10 mg minimum of free lutein, 2 mg zeaxanthin per capsule
  5. AOR Strontium Support II, 341 mg strontium (from citrate) per capsule (two capsules daily)
  6. Nature Made Multi for Him, No Iron (Not a typo. My husband and I both take this multivitamin.)
  7. Nature Made Vitamin C, 500 mg
  8. Solgar Natural Vitamin E (as d-Alpha Tocopherol plus d-Beta, d-Delta and d-Gamma Tocopherols), 400 IU
  9. Nature’s Way Primadophilus bifidus (This is a probiotic.)
10. Solgar Sublingual Methylcobalamin, 5000 mcg
11. Solgar Zinc (as zinc gluconate), 50 mg

I have made a few changes since my last daily supplements update on June 11, 2015:

http://strontiumforbones.blogspot.com/2015/06/my-daily-supplements.html

The most significant change was the switch from Doctor’s Best Strontium Bone Maker to AOR Strontium Support II. I made this change after Doctor’s Best was sold to a Chinese company and before discovering that Doctor's Best Strontium was discontinued in July 2016 (60- and 120-count bottles) and September 2016 (360-count bottle).  

I reduced my dosage of Bluebonnet Lecithin from two to one softgel, which is a serving per the label. Many years earlier, I had been taking three softgels per day. The reason for my latest dosage reduction is that there is currently some controversy about the health benefits of lecithin. I’ve been taking it for many years for cardiovascular health.

https://en.wikipedia.org/wiki/Lecithin  See the introduction and the section on “Biology” in Wikipedia for an overview of lecithin, choline, and phospholipids, such as phosphatidylcholines, a class of phospholipids that incorporate choline as a head group.  

https://www.ncbi.nlm.nih.gov/pubmed/26108618  “Effects of choline on health across the life course: a systematic review.”

I also switched from Nature’s Bounty Vitamin E to Solgar Vitamin E, from Twin Labs Zinc to Solgar Zinc, and from Country Life Citrus Bioflavonoids and Rutin to Solgar Citrus Bioflavonoid Complex. These changes were due solely to unavailability at my online supplement distributor, iherb.com, which no longer stocks Nature’s Bounty Vitamin E or Twin Labs Zinc. Country Life Citrus Bioflavonoids and Rutin is out of stock at iherb.com until 12/25/2016. I may buy whichever bioflavonoid brand is available when I reorder.

I like my supplier’s next day air expedited shipping (at extra cost) because some vitamins and supplements are heat labile. I am unhappy with its current policy of giving a discount, based on total amount of current invoice, for my NEXT purchase rather than for my CURRENT purchase, as was previously done. This policy has raised my costs. 


Wandering Skeleton

Wandering Skeleton
Artist: Joel Hoekstra

Osteoporotic Bone

Osteoporotic Bone
Source: www.mayoclinic.com

How Strontium Builds Bones

Strontium is a mineral that tends to accumulate in bone. Studies have shown that oral doses of strontium are a safe and effective way to prevent and reverse osteoporosis. Doses of 680 mg per day appear to be optimal. See my "For More Information About Strontium" links section.

Osteoporosis is caused by changes in bone production. In healthy young bones there is a constant cycle of new bone growth and bone removal. With age, more bone is removed and less new bone is produced. The bones become less dense and thus more fragile.

Scientists believe that strontium works in two ways. It may stimulate the replication of pre-osteoblasts, leading to an increase in osteoblasts (cells that build bone). Strontium also directly inhibits the activity of osteoclasts (cells that break down bone). The result is stronger bones.

When taking strontium, be sure to take 1200 mg calcium, 1000 IU vitamin D3, and 500 mg magnesium daily. It is best to take strontium late at night on an empty stomach. Calcium and strontium may compete with each other for absorption if taken together.