A German paper by G. Lehmann, G. Hein, and G. Wolf addresses the osteoporosis patient with renal insufficiency and what has to be taken into account in the selection and administration of medications for osteoporosis. Because the incidence of osteoporosis and renal insufficiency increases with age, the use of antiosteoporotic drugs approved for long-term administration in patients with inadequate renal function is a cause for concern. In the dose approved for the treatment of osteoporosis, oral bisphosphonates and i.v. ibandronate (3 mg every 12 weeks) are considered safe in patients with glomerular filtration rate (GFR) > 30 ml/min. Treatment with strontium ranelate and the osteoanabolic substance teriparatide is not altered by impaired renal function until GFR falls below 30 ml/min. Efficiency of the selective estrogen receptor modulator (SERM) raloxifene is not altered by renal function.
http://www.ncbi.nlm.nih.gov/pubmed/16924452
WELCOME TO STRONTIUM FOR BONES BLOG
Have you experienced or read about negative, and even dangerous, side effects from Fosamax (alendronate), Boniva (ibandronate), Actonel (risedronate), and other bisphosphonates prescribed for osteoporosis? If you have, then rest assured there is a safe, effective treatment for this condition. Strontium, primarily in the form of strontium citrate, is taken orally once a day. Studies have shown the bones it rebuilds may be stronger than those rebuilt by the bisphosphonates.
My blog offers visitors useful posts, which you may reply to, information concerning the use of strontium for osteoporosis, and an extensive link library of references. Your participation in occasional polls is welcome.
All comments to my posts are moderated by me.
My blog offers visitors useful posts, which you may reply to, information concerning the use of strontium for osteoporosis, and an extensive link library of references. Your participation in occasional polls is welcome.
All comments to my posts are moderated by me.
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Saturday, September 18, 2010
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How Strontium Builds Bones
Strontium is a mineral that tends to accumulate in bone. Studies have shown that oral doses of strontium are a safe and effective way to prevent and reverse osteoporosis. Doses of 680 mg per day appear to be optimal. See my "For More Information About Strontium" links section.
Osteoporosis is caused by changes in bone production. In healthy young bones there is a constant cycle of new bone growth and bone removal. With age, more bone is removed and less new bone is produced. The bones become less dense and thus more fragile.
Scientists believe that strontium works in two ways. It may stimulate the replication of pre-osteoblasts, leading to an increase in osteoblasts (cells that build bone). Strontium also directly inhibits the activity of osteoclasts (cells that break down bone). The result is stronger bones.
When taking strontium, be sure to take 1200 mg calcium, 1000 IU vitamin D3, and 500 mg magnesium daily. It is best to take strontium late at night on an empty stomach. Calcium and strontium may compete with each other for absorption if taken together.
Osteoporosis is caused by changes in bone production. In healthy young bones there is a constant cycle of new bone growth and bone removal. With age, more bone is removed and less new bone is produced. The bones become less dense and thus more fragile.
Scientists believe that strontium works in two ways. It may stimulate the replication of pre-osteoblasts, leading to an increase in osteoblasts (cells that build bone). Strontium also directly inhibits the activity of osteoclasts (cells that break down bone). The result is stronger bones.
When taking strontium, be sure to take 1200 mg calcium, 1000 IU vitamin D3, and 500 mg magnesium daily. It is best to take strontium late at night on an empty stomach. Calcium and strontium may compete with each other for absorption if taken together.
For More Information About Strontium
- A Dose-response Study With Strontium Malonate
- Additional Positive Phase II Data for Strontium Malonate
- Antifracture Efficacy Over 10 Years With Strontium Ranelate
- Correction Of BMD For Strontium
- International Osteoporosis Foundation
- Long-Term BMD Increases with Strontium Ranelate
- National Osteoporosis Foundation
- Osteoporosis And Bone Physiology
- Osteoporosis Info: Mayo Clinic
- Photo Of Lead Researcher in Strontium Citrate Clinical Trial
- Post-Marketing Assessment of the Safety of Strontium Ranelate
- PREVOS And STRATOS Clinical Trials Of Strontium For Treating Osteoporosis
- Protelos After Long-Term Bisphosphonate Use
- PubMed Abstract On The SOTI Study
- PubMed Abstract On The TROPOS Study
- Servier and NPS Communication on Protos
- Strontium Citrate Osteoblast Study
- Strontium Dexa Scan Effect
- Strontium Malonate for Osteoporosis Accepted by US FDA
- Strontium Malonate Phase II Trial Meets Primary Endpoint
- Strontium Ranelate (Protelos)
- Strontium Ranelate For Spinal Osteoarthritis
- Strontium Ranelate For Women Aged 80 And Older
- Strontium: Breakthrough Against Osteoporosis
- Tests For Causes of Osteoporosis
- Thirteen Key Diagnostic Tests
- VTE In Patients Taking Strontium Ranelate
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