Skeleton Pirate

Skeleton Pirate
Artist: LindaB


Have you experienced, or read about, negative, and even dangerous, side effects from Fosamax (alendronate), Boniva (ibandronate), Actonel (risedronate), and other bisphosphonates prescribed for osteoporosis? If you have, then rest assured there is a safe, effective treatment for this condition. Strontium, primarily in the form of strontium citrate, is taken orally once a day.

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Wednesday, November 11, 2015

Amino Acid Intake and BMD

Jennings et al reported analyses of female identical twins with different amino acid intakes.

Twins with higher intakes of alanine and glycine had higher BMD at the spine than their co-twins, with within-pair differences in spine BMD of 0.012 g/cm2 and 0.014 g/cm2, respectively.

In cross-sectional multivariable analyses of 3,160 females aged 18-79 years, a higher intake of total protein was associated with higher BMD at the spine (quartile Q4 to quartile Q1: 0.017 g/ cm2) and forearm (Q4 to Q1: 0.010 g/cm2.

Intake of alanine, arginine, glutamic acid, leucine, lysine, and proline was associated with higher BMD at the spine and forearm, with the strongest association observed for leucine (Q4 to Q1: 0.024 g/cm2).

When intakes were stratified by source, vegetable or animal, prevalence of osteoporosis or osteopenia was 13% to 19% lower comparing extreme quartiles of vegetable intake for five amino acids (not glutamic acid or proline).

Jennings A, MacGregor A, Spector T, Cassidy A. Amino acid intakes are associated with bone mineral density and prevalence of low bone mass in women: Evidence from discordant monozygotic twins. J Bone Miner Res 2015; doi:10.1002/jbmr.2703.


Anonymous said...

Hello, After much reading I am a little confused. I have been prescribed Stontium ranelate, but am reluctant to take it, mainly because of the aspartame and because it is synthetic.
Will the strontium citrate do the same job? All the reports I read about 'ranelate' are positive, hence the confusion. I just cant seem to get my head around it all :(

BoneLady said...

To: Anonymous of 11/11/2015

I believe strontium citrate will do the same job as strontium ranelate because it appears to be strontium that exerts most or all of the positive effect on bone.

“Studies to date have predominantly focused on strontium ranelate rather than the readily available strontium citrate supplement as used in this study [Combination of Micronutrients for Bone (COMB) Study]. The results of this study, however, demonstrate that the micronutrient combination including strontium citrate is at least as effective in BMD change as strontium ranelate with suggestion of preferred efficacy of the former therapy at improving femoral neck outcomes. Furthermore, the ranelic acid salt is a purely synthetic molecular compound, while citrate is naturally occurring. It appears to be the strontium portion of the molecules which exerts most or all of the positive effect on bone.”

I have been taking strontium citrate (Doctor's Best Strontium Bone Maker, 1944 mg strontium citrate, 680 mg elemental strontium in two capsules) for almost eight years. My BMD has shown significant improvement with each subsequent DXA scan. I began with osteoporosis, was at the osteopenia stage more than two years ago,and am probably normal today. My next DXA scan will tell.

I have had none of the side effects associated with strontium ranelate. I had mild constipation at first but corrected the problem by increasing my fiber.

I wish you good health, whatever you desire to take. Let me know if you have further questions.

Anonymous said...

Thank you so much, I now understand - I have ordered the Dr's Best and that is what I shall take.
Have a blessed weekend - Catherine ♥

Wandering Skeleton

Wandering Skeleton
Artist: Joel Hoekstra

Osteoporotic Bone

Osteoporotic Bone

How Strontium Builds Bones

Strontium is a mineral that tends to accumulate in bone. Studies have shown that oral doses of strontium are a safe and effective way to prevent and reverse osteoporosis. Doses of 680 mg per day appear to be optimal. See my "For More Information About Strontium" links section.

Osteoporosis is caused by changes in bone production. In healthy young bones there is a constant cycle of new bone growth and bone removal. With age, more bone is removed and less new bone is produced. The bones become less dense and thus more fragile.

Scientists believe that strontium works in two ways. It may stimulate the replication of pre-osteoblasts, leading to an increase in osteoblasts (cells that build bone). Strontium also directly inhibits the activity of osteoclasts (cells that break down bone). The result is stronger bones.

When taking strontium, be sure to take 1200 mg calcium, 1000 IU vitamin D3, and 500 mg magnesium daily. It is best to take strontium late at night on an empty stomach. Calcium and strontium may compete with each other for absorption if taken together.