Skeleton Pirate

Skeleton Pirate
Artist: LindaB

WELCOME TO STRONTIUM FOR BONES BLOG

Have you experienced, or read about, negative, and even dangerous, side effects from Fosamax (alendronate), Boniva (ibandronate), Actonel (risedronate), and other bisphosphonates prescribed for osteoporosis? If you have, then rest assured there is a safe, effective treatment for this condition. Strontium, primarily in the form of strontium citrate, is taken orally once a day.

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Thursday, September 4, 2014

Strontium and Renal Impairment

Is it safe to take strontium for osteoporosis when a patient has reduced kidney function? This question came up recently in a health forum. The patient had been taking strontium citrate for four years, but recently, her eGFR (estimated glomerular filtration rate) had decreased to 49 ml/min, which is considered a moderate decrease in GFR. She was wondering if she could continue taking strontium citrate.

Unfortunately, there are no data relating directly to strontium citrate and reduced kidney function. However, because strontium citrate and strontium ranelate are strontium salts and share some characteristics, we can look at the summary of product characteristics (SPC) for Protelos (strontium ranelate) to arrive at a reasonable answer for strontium citrate. That SPC states that strontium ranelate is not recommended for patients with severe renal impairment (creatinine clearance below 30 ml/min). No dose adjustment is required in patients with mild-to-moderate renal impairment (30-70 ml/min creatinine clearance).

http://www.servier.com/sites/default/files/ProtelosSPCApril2014.pdf

The National Kidney Foundation states normal values for eGFR are 90-120 ml/min. An eGFR below 60 ml/min suggests that some kidney damage has occurred. For information on the eGFR, see:

http://labtestsonline.org/understanding/analytes/gfr/tab/test/

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Wandering Skeleton

Wandering Skeleton
Artist: Joel Hoekstra

Osteoporotic Bone

Osteoporotic Bone
Source: www.mayoclinic.com

How Strontium Builds Bones

Strontium is a mineral that tends to accumulate in bone. Studies have shown that oral doses of strontium are a safe and effective way to prevent and reverse osteoporosis. Doses of 680 mg per day appear to be optimal. See my "For More Information About Strontium" links section.

Osteoporosis is caused by changes in bone production. In healthy young bones there is a constant cycle of new bone growth and bone removal. With age, more bone is removed and less new bone is produced. The bones become less dense and thus more fragile.

Scientists believe that strontium works in two ways. It may stimulate the replication of pre-osteoblasts, leading to an increase in osteoblasts (cells that build bone). Strontium also directly inhibits the activity of osteoclasts (cells that break down bone). The result is stronger bones.

When taking strontium, be sure to take 1200 mg calcium, 1000 IU vitamin D3, and 500 mg magnesium daily. It is best to take strontium late at night on an empty stomach. Calcium and strontium may compete with each other for absorption if taken together.