The optimal level of calcium intake to compensate for skeletal calcium losses and to prevent osteoporosis and fractures remains unclear. This is reflected by the wide range of daily calcium recommendations for individuals older than 50 years: at present 700 mg in the UK, 800 mg in Scandinavia, 1200 mg in the United States, and 1300 mg in Australia and New Zealand.
The findings of a large Swedish study recently published in the British Medical Journal show an association between a low habitual dietary calcium intake (below 751 mg per day for women) and an increased risk of fractures and of osteoporosis. Above this base level, only minor differences in risk were observed. The highest reported calcium intake (>1137 mg) did not further reduce the risk of fractures of any type, or of osteoporosis, but was associated with a higher rate of hip fracture.
Eva Warensjö, et al. BMJ. 2011; 342: d1473.
Published online 2011 May 24. doi: 10.1136/bmj.d1473.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3101331/
Skeleton Pirate
Artist: LindaB
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Wandering Skeleton
Artist: Joel Hoekstra
Osteoporotic Bone
Source: www.mayoclinic.com
How Strontium Builds Bones
For More Information About Strontium
- A Dose-response Study With Strontium Malonate
- Additional Positive Phase II Data for Strontium Malonate
- Antifracture Efficacy Over 10 Years With Strontium Ranelate
- Correction Of BMD For Strontium
- International Osteoporosis Foundation
- Long-Term BMD Increases with Strontium Ranelate
- National Osteoporosis Foundation
- Osteoporosis And Bone Physiology
- Osteoporosis Info: Mayo Clinic
- Photo Of Lead Researcher in Strontium Citrate Clinical Trial
- Post-Marketing Assessment of the Safety of Strontium Ranelate
- PREVOS And STRATOS Clinical Trials Of Strontium For Treating Osteoporosis
- Protelos After Long-Term Bisphosphonate Use
- PubMed Abstract On The SOTI Study
- PubMed Abstract On The TROPOS Study
- Servier and NPS Communication on Protos
- Strontium Citrate Osteoblast Study
- Strontium Dexa Scan Effect
- Strontium Malonate for Osteoporosis Accepted by US FDA
- Strontium Malonate Phase II Trial Meets Primary Endpoint
- Strontium Ranelate (Protelos)
- Strontium Ranelate For Spinal Osteoarthritis
- Strontium Ranelate For Women Aged 80 And Older
- Strontium: Breakthrough Against Osteoporosis
- Tests For Causes of Osteoporosis
- Thirteen Key Diagnostic Tests
- VTE In Patients Taking Strontium Ranelate
4 comments:
I am new to this blog, I hope I am posting this properly.
And I am new to all of this. I have read many positive things about Strontium and I bought a bottle and took it yesterday. Then I read: Vivian Goldschmidt, MA , on her web site Save Our Bones states: “Strontium in all its forms, as studies reveal, contributes to bone thickening rather than to the quality of bone mineral. In other words, the outer cortical bone becomes thicker – reducing tensile strength – and therefore, it can be logically implied that bones with a thicker outer cortex are more prone to breakage or fracture.” http://saveourbones.com/vivian-answers-day-7/.
This is confusing. Is she off base? I appreciate your answer.
BeteB,
The Save Our Bones website is a commercial one for selling Vivian Goldschmidt’s books. Her statement about strontium takes a partial truth (“the outer cortical bone becomes thicker”), ignores the fact that strontium also affects trabecular bone, and reaches the erroneous conclusion that somehow increased cortical thickness reduces tensile strength.
Here are the facts based on analysis of transiliac bone biopsy samples from phase 2 and 3 clinical trials of strontium ranelate: Strontium improves the microarchitecture of both trabecular and cortical bone. At the trabecular level, strontium significantly increases trabecular number by 14% and decreases trabecular separation by 16%, shifting trabeculae from rod-like structures to plate-like patterns. At the cortical level, strontium enlarges cortical bone dimensions by increasing cortical thickness by 18%. The change in 3D trabecular and cortical microarchitecture may improve bone biomechanical competence and explain the decreased fracture rate after strontium use.
Bone Lady is right. The TROPOS and SOTI numbers are the bottom line. Strontium works.
As to thickening the outer cortex to strenthen a bone...the state of Californa put steel jackets around bridge supports and that "stiffening" kept those supports from collaspsing in subsequent earthquakes.
http://www.exploratorium.edu/faultline/damage/retro.html
Besides, there are credible reports attesting to the high quality of bone formation in patients on strontium.
http://www.ncbi.nlm.nih.gov/pubmed/21276882
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2908746/
http://onlinelibrary.wiley.com/doi/10.1359/jbmr.091028/abstract;jsessionid=1A8FA809406F34CD14190BBA198F8E59.d02t02
Mom of three,
Thank you for your comments about strontium and the scholarly links. I love your analogy comparing taking strontium to increase cortical thickness and strengthen bone with putting steel jackets around bridge supports to strengthen those supports. However, the reduced fracture risk associated with strontium appears to result from changes to both cortical and trabecular bone. Expanding on your analogy, I would say that taking strontium is like putting steel jackets around bridge supports and repairing the bridge itself.
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