Skeleton Pirate

Skeleton Pirate
Artist: LindaB


Have you experienced, or read about, negative, and even dangerous, side effects from Fosamax (alendronate), Boniva (ibandronate), Actonel (risedronate), and other bisphosphonates prescribed for osteoporosis? If you have, then rest assured there is a safe, effective treatment for this condition. Strontium, primarily in the form of strontium citrate, is taken orally once a day.

Visitors to my blog can leave comments or ask questions and can remain anonymous, if they wish. Their comments are relayed to my g-mail inbox. Below each post, the number of comments for that post is cited and underlined because it is a link. By clicking on that link below any post, a window opens so that a visitor can leave a comment. Ideally, visitors leave comments on posts most relevant to their comments. All comments to my posts are moderated by me.

Browse the posts and visit the link library of references.

Visit me at

Blog Archive

Thursday, April 21, 2011

Drugs Associated With Increased Bone Loss And Fracture Risk

"Certain drugs (e.g., glucocorticoids, carbamazepine, phenytoin, valproic acid, lithium, depot medroxyprogesterone, chemotherapeutic agents, and long-term heparin therapy) are known to be associated with increases in bone loss or fracture rate. Thiazolidinediones are the newest addition to this list, as recent clinical trials have reported increased fracture rates in patients receiving these drugs for the treatment of type 2 diabetes mellitus."

"Pioglitazone and rosiglitazone, the two currently available thiazolidinediones, accounted for nearly one quarter of the antidiabetic drugs prescribed in the United States in 2004 and 2005. In 2008, both pioglitazone (8th) and rosiglitazone (98th) ranked within the top 100 prescription drug sales in the United States. This widespread use has exposed many postapproval adverse effects, including bone changes and fractures."

The entire article can be read at:
Bone Loss and Fracture Risk Associated with Thiazolidinedione Therapy
Daniel M. Riche, Pharm.D.; S. Travis King, Pharm.D.
Posted: 10/05/2010; Pharmacotherapy


Wolfy said...

You list is a great resource for those patients who either have or want to prevent osteoporosis. Many drugs can cause osteoporosis or worsten it so your list makes it easy to find that kind of info.

BoneLady said...

On 04/30/11, William Croft wrote the following:

"Thanks for your great blog, I just signed up using Google Reader (RSS) and that makes it much easier to scan through your past topics. Would you mind updating your About Me blurb on the home page to include your recent results, since those figures are from 2007. (Mentioning that your first followup would be 2009.) Best regards, William Croft"

I have added a link at the end of my "About Me" profile to make it easier to find my July, 2009, followup DXA scan results.

BoneLady said...

On 05/01/11, William Croft made the following comment (edited) on this blog:

"Another factor you might mention in reduction of bone density, is the subject's general stress level. So that treatment strategies need to include stress reduction methodologies as well as supplementation."

I believe stress can play havoc with our bodies and affect our health in many ways. Exercise is one excellent way of reducing stress. There are many others, including massage, aroma therapy,and meditation.

The best bone-building strategies are multi-pronged: supplementation with strontium, calcium, magnesium, vitamins D and K, and essential fatty acids; exercises, such as walking, weight training, and core strengthening; a good diet that includes adequate protein, whole grains, vegetables and fruits, and a calcium source.

Best regards,


Wandering Skeleton

Wandering Skeleton
Artist: Joel Hoekstra

Osteoporotic Bone

Osteoporotic Bone

How Strontium Builds Bones

Strontium is a mineral that tends to accumulate in bone. Studies have shown that oral doses of strontium are a safe and effective way to prevent and reverse osteoporosis. Doses of 680 mg per day appear to be optimal. See my "For More Information About Strontium" links section.

Osteoporosis is caused by changes in bone production. In healthy young bones there is a constant cycle of new bone growth and bone removal. With age, more bone is removed and less new bone is produced. The bones become less dense and thus more fragile.

Scientists believe that strontium works in two ways. It may stimulate the replication of pre-osteoblasts, leading to an increase in osteoblasts (cells that build bone). Strontium also directly inhibits the activity of osteoclasts (cells that break down bone). The result is stronger bones.

When taking strontium, be sure to take 1200 mg calcium, 1000 IU vitamin D3, and 500 mg magnesium daily. It is best to take strontium late at night on an empty stomach. Calcium and strontium may compete with each other for absorption if taken together.