Skeleton Pirate

Skeleton Pirate
Artist: LindaB


Have you experienced, or read about, negative, and even dangerous, side effects from Fosamax (alendronate), Boniva (ibandronate), Actonel (risedronate), and other bisphosphonates prescribed for osteoporosis? If you have, then rest assured there is a safe, effective treatment for this condition. Strontium, primarily in the form of strontium citrate, is taken orally once a day.

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Wednesday, August 19, 2009

Comparison of Strontium Malonate to Strontium Ranelate

Currently, Osteologix’s primary goal is to obtain approval for NB S101 (strontium malonate) for the treatment and prevention of osteoporosis. Their phase I study of the pharmacokinetic, or PK, properties of NB S101 revealed that a one gram tablet dose of NB S101 resulted in approximately the same level of strontium in human serum as a European company's approved product containing two grams of strontium ranelate in sachet formulation, which must be mixed with water before ingestion. Thus, at a significantly lower dose, their tablet formulation of strontium has shown bioequivalent levels of strontium to a marketed sachet product that has been proven safe and effective in osteoporotic patients in Europe.

More importantly, the recent results of their phase II study demonstrated that NB S101 decreased an established biomarker of bone resorption, CTX-1, in a dose-dependent manner by an amount statistically equivalent to or superior to the product approved in Europe. The phase II results also showed that NB S101 significantly increased bone mineral density at the lumbar spine and hip with only 12 weeks of treatment, and no significant side effects were noted in the trial.


Anonymous said...

I just had a bone density test and am very disappointed but am definitely going to stay with the Strontium Citrate and raw Calcium supplements. I'm 73, had breast cancer and had to take an estrogen reducing drug and also on steroid inhaler for asthma. I stopped Actonel Nov. 2009 after years of being on it. It had brought me up to near the top range of Osteopenia but as of last week I am back down to borderline osteoporosis AND I have two compression deformities which the dr. called 'fractures'. AND I just had back surgery for a slipped vertebra among other things. My bones are 'soft' according to spine surgeon.
I was on Strontium and raw calcium for several bottles last year or the year before then switched to something else but got back on that previous product about 6 months ago and hoped the bone density would have shown that I was 'stable'. Obviously the estrogen reducing drug (Anastrazole)that I was on for 3 years and stopped myself last month, and the steroid have done their worst. I'm so glad to have found your site to read these results and comments from everyone because I absolutely do not want to take any more drugs and the osteoporosis drugs sound like the worst. I'm desperately trying to figure out what to do and I will continue with the Strontium. My primary doctor asked if I was on it but my Rheumatologist said she goes to all the conventions of the Osteo.Fndtn. and she's never heard anyone say anything about Strontium. Another anti-drug site I was on gave negative comments about it but I'm thinking that she may not have all the facts such as you have here on this site, and when I read it I was almost going to refuse to take Strontium anymore esp. considering my latest results, but now I've found this site that tells me what I need to hear. I appreciate what everyone has to say about their experience and results. I hope next year I'll have better results also.

BoneLady said...


I’m sorry to hear your latest BMD results were disappointing but glad you plan to continue taking strontium citrate and calcium. You said that, for three years, you had been on an estrogen-reducing drug (Anastrazole) for breast cancer, but you stopped taking it a month ago. I assume you are still using a steroid inhaler for asthma. In other words, you have been fighting an uphill battle, through no fault of your own, by having to take drugs known to cause or worsen osteoporosis.

First, ask your doctor if he can prescribe an alternative to the asthma inhaler. The drugs Singulair and Accolate proved to be just as effective as steroid inhalers for the prevention of asthma symptoms with better patient compliance in two studies published in the New England Journal of Medicine. Both drugs are leukotriene receptor antagonists (LTRAs) and both were approved more than a decade ago as alternatives to “preventer” inhalers. But they are not as widely used and some studies have found them to be less effective for asthma control in patients with mild persistent asthma.

Also, ask your doctor to order a 25-hydroxy vitamin D test to check your vitamin D blood level. Many people who fracture have low vitamin D levels. Depending on the results of your vitamin D test, add sufficient vitamin D to your other supplements.

Then, stay the course with the strontium and calcium. Make sure you are taking strontium and calcium at least two to four hours apart because they compete with each other for absorption. Your strontium citrate should be from a reliable brand. The most effective dose for treating osteoporosis is 680 mg elemental strontium per day.

Your need for calcium supplementation depends on how much calcium you are getting from your diet. It is best to get all or most of your calcium from your diet. The total from diet and supplementation should equal 1200 mg calcium.

Magnesium is necessary for calcium metabolism. Adults need 250-500 mg magnesium daily from diet and supplements. If you are a heavy consumer of nuts, seeds, and green vegetables, or live in an area with hard water, you probably get ample magnesium.

Anyone who reads my blog understands that I believe in supplementing with strontium citrate and other supplements for bone and general health. Thank you for writing. Please keep in touch. I wish you the best of health.

Wandering Skeleton

Wandering Skeleton
Artist: Joel Hoekstra

Osteoporotic Bone

Osteoporotic Bone

How Strontium Builds Bones

Strontium is a mineral that tends to accumulate in bone. Studies have shown that oral doses of strontium are a safe and effective way to prevent and reverse osteoporosis. Doses of 680 mg per day appear to be optimal. See my "For More Information About Strontium" links section.

Osteoporosis is caused by changes in bone production. In healthy young bones there is a constant cycle of new bone growth and bone removal. With age, more bone is removed and less new bone is produced. The bones become less dense and thus more fragile.

Scientists believe that strontium works in two ways. It may stimulate the replication of pre-osteoblasts, leading to an increase in osteoblasts (cells that build bone). Strontium also directly inhibits the activity of osteoclasts (cells that break down bone). The result is stronger bones.

When taking strontium, be sure to take 1200 mg calcium, 1000 IU vitamin D3, and 500 mg magnesium daily. It is best to take strontium late at night on an empty stomach. Calcium and strontium may compete with each other for absorption if taken together.