Skeleton Pirate
Artist: LindaB
WELCOME TO STRONTIUM FOR BONES BLOG
Have you experienced negative, and even dangerous, side effects from Fosamax (alendronate), Boniva (ibandronate), Actonel (risedronate), Reclast (zoledronic acid), Prolia (denosumab), Forteo (teriparatide), Tymlos (abaloparatide), or other drugs prescribed for osteoporosis? If you have, then rest assured there is a safe, effective treatment for this condition. Strontium, primarily in the form of strontium citrate, is taken orally once a day.
Visitors to my blog can leave comments or ask questions and can remain anonymous, if they wish. Their comments are relayed to my g-mail inbox. Below each post, the number of comments for that post is cited and underlined because it is a link. By clicking on that link below any post, a window opens so that a visitor can leave a comment. Ideally, visitors leave comments on posts most relevant to their comments. All comments to my posts are moderated by me.
Browse the posts and visit the link library of references.
Visitors to my blog can leave comments or ask questions and can remain anonymous, if they wish. Their comments are relayed to my g-mail inbox. Below each post, the number of comments for that post is cited and underlined because it is a link. By clicking on that link below any post, a window opens so that a visitor can leave a comment. Ideally, visitors leave comments on posts most relevant to their comments. All comments to my posts are moderated by me.
Browse the posts and visit the link library of references.
Wednesday, April 8, 2009
A Dose-Response Study With Strontium Malonate
Osteologix, Inc. is conducting a Phase II clinical trial with strontium malonate in postmenopausal women. The study's primary objective is to compare dose-response effect of three levels of strontium malonate to placebo on bone resorption quantified by S-CTX-1 following 12 weeks of treatment. The four parallel groups in this trial will take 750 mg strontium malonate, 1000 mg strontium malonate, 2000 mg strontium malonate, 2 grams Protelos (strontium ranelate), and placebo. For more details, visit http://clinicaltrials.gov/ct2/show/NCT00409032
Subscribe to:
Post Comments (Atom)
Wandering Skeleton
Artist: Joel Hoekstra
Osteoporotic Bone
Source: www.mayoclinic.com
How Strontium Builds Bones
Strontium is a mineral that tends to accumulate in bone. Studies have shown that oral doses of strontium are a safe and effective way to prevent and reverse osteoporosis. Doses of 680 mg per day appear to be optimal. See my "For More Information About Strontium" links section.
Osteoporosis is caused by changes in bone production. In healthy young bones there is a constant cycle of new bone growth and bone removal. With age, more bone is removed and less new bone is produced. The bones become less dense and thus more fragile.
Scientists believe that strontium works in two ways. It may stimulate the replication of pre-osteoblasts, leading to an increase in osteoblasts (cells that build bone). Strontium also directly inhibits the activity of osteoclasts (cells that break down bone). The result is stronger bones.
When taking strontium, be sure to take 1200 mg calcium, 1000 IU vitamin D3, and 500 mg magnesium daily. It is best to take strontium late at night on an empty stomach. Calcium and strontium may compete with each other for absorption if taken together.
Osteoporosis is caused by changes in bone production. In healthy young bones there is a constant cycle of new bone growth and bone removal. With age, more bone is removed and less new bone is produced. The bones become less dense and thus more fragile.
Scientists believe that strontium works in two ways. It may stimulate the replication of pre-osteoblasts, leading to an increase in osteoblasts (cells that build bone). Strontium also directly inhibits the activity of osteoclasts (cells that break down bone). The result is stronger bones.
When taking strontium, be sure to take 1200 mg calcium, 1000 IU vitamin D3, and 500 mg magnesium daily. It is best to take strontium late at night on an empty stomach. Calcium and strontium may compete with each other for absorption if taken together.
For More Information about Strontium
- A Dose-response Study With Strontium Malonate
- A Review of the latest insights into the mechanism of action of strontium in bone
- Antifracture Efficacy Over 10 Years With Strontium Ranelate
- Combination of Micronutrients for Bone (COMB) Study: Bone Density after Micronutrient Intervention
- Echolight REMS Scan of Young, Normal Female
- Effect of bone strontium on BMD measurements
- Effect of Lumbar Scoliosis on DXA Results
- Effects of SrR on Calcium Metabolism
- Effects of strontium ions on growth and dissolution of hydroxyapatite and on bone mineral detection
- Influence of strontium on bone mineral density and bone mineral content measurements by dual X-ray absorptiometry
- Interpretation of BMD Scans in Patients Stopping Strontium
- Melatonin-micronutrients Osteopenia Treatment Study (MOTS)
- National Osteoporosis Foundation
- Osteoporosis And Bone Physiology
- Post-Marketing Assessment of the Safety of Strontium Ranelate
- PubMed Abstract On The SOTI Study
- PubMed Abstract On The TROPOS Study
- Strontium ranelate Aristo
- Strontium Ranelate For Spinal Osteoarthritis
- Strontium: Breakthrough Against Osteoporosis
- Summary Safety Review - Strontium
- The Influence of Strontium on Bone Tissue Metabolism and Its Application in Osteoporosis Treatment
- Thirteen Key Diagnostic Tests
3 comments:
Hi Bone Lady,
Thanks for your blog. I have been taking Strontium Citrate for almost 3 years. I'm only 52 but have pretty serious osteoporosis because I went through menopause around age 40. A hysterectomy at 32 brought it on early, although I wasn't aware I went through menopause except for some weight gain and fatigue. (Anyone reading this who has had a hysterectomy should insist on a bone scan 10 years later. In all the "rate your chances of getting osteoporosis" tests, I still get a "very low chance" rating.) After my scary birthday gift to myself at 50 (getting a full checkup, first one in a decade), my awesome doctor gave me the scan on a pure hunch. He discovered several medical conditions, one of them the appalling and unacceptable osteoporosis. I am a hiker, biker and kayaker. So after about 10 minutes on Actonel and Fosamax in 2006, I got the creeps and quit taking it. (A friend told me "You know why they call it Fosamax, don't you? It turns your bones to fossils!") Luckily my doctor is very open-minded and educated and put me on Strontium Citrate. Because there was the medicine change, I got a bone density test one year later and density had improved exponentially. So I got my 2-year last week. I knew it would be great because I do everything right - calcium-magnesium-Vit D, all the yogurt I want, at least 35 min. of fast walking every day, yoga, good rest, a good diet, never smoked, don't drink pop, hardly ever drink alcohol, drink limited amounts of decaf. Everything right! I was shocked to learn my spine went from -2.7 to-3.3 in 2 years! My hips improved slightly but I was so wigged out I can't remember those stats. After going on a long walk with my husband (crying all the way, disbelief, anger, frustration) I came home and read online for hours at WebMD about all the treatments, expecting the doc would decide it was Boniva time. But the blogs on WebMD left me cold. No chance of going back to that nonsense. After hours of reading, I noticed WebMD did not rate Strontium, so it occurred to me I should google strontium citrate and that's when I found your blog. Slowly it dawned on me that strontium is just fine, but I had been taking it wrong, and not enough. I hate taking anything, so I just took it all at once. The calcium completely absorbed the strontium. When the nurse called to tell me the Doc prescribed a higher dose for a while, I told her about my moronic discovery. She said all of their patients have improved dramatically with Strontium, with no side effects. So the only thing I did wrong was not be disciplined enough. I made up a chart of all the stuff I have to take, and when, and when I should eat. BTW, my other conditions are hypothyroid and acid reflux. I don't take synthetic thyroid because that interferes with bone density. (A former vegetarian, I am grateful to the pigs and thank them daily.) I can't help but think the three conditions are related and some enterprising researcher will find a connection between them and how they affect metabolism and absorption. I get my Strontium by Ortho Molecular Products from the clinic, and my doctors research it thoroughly before they sell anything there. I feel very fortunate that we caught the problem. Thanks for providing all the good research on your blog, and I hope your scan in May turns out to be fabulous!
Could you post some of your discoveries about taking supplements - the right amount at the right times? I too, refused a medicine - Forteo. I am trying to solve the problem with exercise, food, and supplements. I have been taking Strontium for about 2 years (680 per day), checking my acid/alkaline daily and supplementing with bioplasma, calcium, D, salmon oil, K2, etc. My 1 yr checkup was great but my exercise program was more intense then (kickboxing, walks, weights). I am worried about going for the 2nd yr checkup.
To Anonymous Poster of 08/01/2010:
In March, 2010, I wrote three posts about supplements:
03/30/2010, "How Much Calcium Are You Getting?" (Includes link to IOF's Calcium Calculator)
03/29/2010, "Strontium With Insufficient Calcium and Magnesium, A Case Study"
03/22/2010, "Strontium and Calcium"
I may take your suggestion and add more posts about supplements. I believe each person should follow a healthy lifestyle that includes an adequate diet, supplements, and exercise, geared to his/her individual needs.
I looked up Bioplasma and found it is a combination of 12 Cell Salts, a group of homeopathic remedies made from minerals. I do not take any homeopathic preparations. There is no proof they work, but you may find yours to be beneficial.
I know many people who follow an alkaline diet. I am not one of them. I do not believe the explanation behind it to be scientifically valid. However, such a diet includes plenty of vegetables, and I do incorporate vegetables in my daily diet.
Congratulations on your one-year checkup. Good luck on your second-year checkup.
Post a Comment