Bone fractures and skeletal defects are rising worldwide and require new developments in bone regeneration. Strontium (Sr) is an element that has been investigated for its role in bone remodeling and bone formation. This study is a review of strontium folate (SrFO), a recently developed, non-protein based, bone-promoting agent that is of interest in medical and pharmaceutical fields due to its improved features compared to current therapies for bone diseases.
An aging population has led to a steady increase in the number of musculoskeletal conditions and, in particular, of cartilage and bone surgical procedures. Therefore, the development of alternative materials and strategies in bone replacement therapies is of interest. Above a critical size, bone defects are not repaired by the self-healing system of the tissue. Thus, an osteoconductive and osteoinductive device (or scaffold) is usually required in order to regenerate the lost tissue. The scaffold must be composed of materials that stimulate and favor the formation of new bone tissue and must be structurally stable during the process of cell growth and expansion. In this regard, autografts are still considered the “gold standard.” However, they have many drawbacks, such as limited availability and morbidity of the donor site. Alternatively, a proper scaffold made of a given biomaterial would be desirable both to fill the defect and to act as a reservoir for growth factors and/or cells.
SrFO-based scaffolds increase bone regeneration in vivo. The Sr-based-systems seem to be a useful alternative for the regeneration of bone tissue in complicated defects.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6539601/
Human Skeleton
Monday, December 30, 2019
Thursday, October 17, 2019
Strontium Citrate Protocols
If you decide to take strontium citrate, you need to ensure you are also getting adequate calcium, magnesium, vitamin D, other vitamins and minerals, and protein. You can get these nutrients from a combination of diet and supplements. Choosing a supplement plan, or protocol, that is right for you can be as simple as choosing one of the three protocols described in this post or by modifying one of them with your own choice of supplements.
Protocols for Osteoporosis:
COMB BoneLady
Strontium citrate 680 mg 680 mg
Vitamin K2 (MK7) 100 mcg none
Vitamin D3 2000 IU 1000 IU
Docosahexanoic acid (DHA)250 mg none
Magnesium 25 mg 250 mg*
Calcium Dietary sources 500 mg*
Protocol for Osteopenia:
MOTS
Strontium citrate 450 mg
Vitamin K2 (MK7) 60 mcg
Vitamin D3 2000 IU*
Melatonin 5 mg
DHA none
Magnesium none
Calcium *
*In addition to study medication, participants in the MOTS study were allowed to take less than 1000 IU of vitamin D3 and less than 1000 mg of calcium daily.
Friday, January 11, 2019
Axial DXA 8 January 2019
The report of my axial DXA scan taken on 8 January 2019 appears below. I have been on 2 grams strontium citrate/day for 11 years. I also take a calcium/magnesium tablet (500 mg Ca/250 mg Mg), a multivitamin with 1000 IU vitamin D3, and several other supplements. I get plenty of protein in my diet. I exercise daily.
As you can see, my DXA results were excellent, except for my left femoral neck, which showed no change from the previous scan.
I am happy with my results, although I know the comparison of this year's results to those of 2.5 years ago contains some built-in error because two different brands of DXA machines were used. My 2016 scan was on a Hologic and the 2019 scan was on a GE Lunar Prodigy.
Changing testing sites, and, therefore, machines, was not my choice. I had been getting my scans in the outpatient radiology department of a large hospital medical center, but the provider is now pushing patients into its freestanding imaging centers. I was told my insurance would not pay for a DXA unless it was done at a freestanding center, but my insurance denied that assertion.
The risk factor for secondary osteoporosis mentioned, but not specified, in the report is early menopause.
INDICATION: Postmenopausal. Follow-up of osteopenia on prior DXA.
Patient reports risk factors for secondary osteoporosis.
COMPARISON: 8/4/2016
FINDINGS:
Spine: Total BMD of the spine (L1-4) is 1.108 g/cm2, with a T-score of
-0.7 and a Z-score of 1.0.
Left Femoral Neck: BMD is 0.883 g/cm2, with a T-score of -1.1 and a
Z-score of 0.6.
Left Total Hip: BMD is 0.928 g/cm2, with a T-score of -0.6 and a Z-score
of 0.9.
Right Femoral Neck: BMD is 0.919 g/cm2, with a T-score of -0.9 and a
Z-score of 0.9.
Right Total Hip: BMD is 0.963 g/cm2, with a T-score of -0.4 and a Z-score
of 1.1.
Compared to the prior study, there has been 9% increase in spine density, 6% increase in left total hip density, but no change in left femoral neck density.
FRAX evaluation calculates 10-year probability of fracture:
Major Osteoporotic: 7.8%
Hip: 1.0%
IMPRESSION:
Based on BMD, diagnosis is consistent with osteopenia.
FOLLOWUP: In 2 years is recommended.
As you can see, my DXA results were excellent, except for my left femoral neck, which showed no change from the previous scan.
I am happy with my results, although I know the comparison of this year's results to those of 2.5 years ago contains some built-in error because two different brands of DXA machines were used. My 2016 scan was on a Hologic and the 2019 scan was on a GE Lunar Prodigy.
Changing testing sites, and, therefore, machines, was not my choice. I had been getting my scans in the outpatient radiology department of a large hospital medical center, but the provider is now pushing patients into its freestanding imaging centers. I was told my insurance would not pay for a DXA unless it was done at a freestanding center, but my insurance denied that assertion.
The risk factor for secondary osteoporosis mentioned, but not specified, in the report is early menopause.
INDICATION: Postmenopausal. Follow-up of osteopenia on prior DXA.
Patient reports risk factors for secondary osteoporosis.
COMPARISON: 8/4/2016
FINDINGS:
Spine: Total BMD of the spine (L1-4) is 1.108 g/cm2, with a T-score of
-0.7 and a Z-score of 1.0.
Left Femoral Neck: BMD is 0.883 g/cm2, with a T-score of -1.1 and a
Z-score of 0.6.
Left Total Hip: BMD is 0.928 g/cm2, with a T-score of -0.6 and a Z-score
of 0.9.
Right Femoral Neck: BMD is 0.919 g/cm2, with a T-score of -0.9 and a
Z-score of 0.9.
Right Total Hip: BMD is 0.963 g/cm2, with a T-score of -0.4 and a Z-score
of 1.1.
Compared to the prior study, there has been 9% increase in spine density, 6% increase in left total hip density, but no change in left femoral neck density.
FRAX evaluation calculates 10-year probability of fracture:
Major Osteoporotic: 7.8%
Hip: 1.0%
IMPRESSION:
Based on BMD, diagnosis is consistent with osteopenia.
FOLLOWUP: In 2 years is recommended.
Saturday, December 22, 2018
Strontium Ranelate Returns to UK January 2019
The osteoporosis medication
strontium ranelate (SR) will once again be available in the UK from January
2019.
The drug was previously available under the brand Protelos but was pulled from the UK market in August 2017.
Servier, the manufacturer of the drug at the time, decided to cease supplying it to the UK due to loss of sales. Use of the drug in the UK had been limited by the health authorities due to safety concerns about cardiovascular risks. A continuous decline in the number of people being treated with it led to the company's decision.
Pharmaceutical company Aristo has now taken on the manufacturing of strontium ranelate, which will be available for prescription beginning January 2019, for the treatment of severe osteoporosis in postmenopausal women and adult men who are at high risk of fracture.
This is good news for UK patients who wish to take SR. It is also good news for those of us in the USA and Canada, where SR is not available, but strontium citrate (SC) is. Some people taking SC got scared when SR was pulled from the UK and the EU. I have continuously taken SC for 11 years. Below is a link to the package information for Aristo.
Package leaflet: Information for the
patient
Strontium ranelate Aristo 2 g
granules for oral suspension
Marketing Authorisation Holder
Aristo Pharma GmbH
Wallenroder Straße 8-10
13435 Berlin
Germany
Manufacturer
Lindopharm GmbH
Neustraße 82
40721 Hilden
Germany
Wednesday, September 26, 2018
Strontium Citrate Products
Although I have occasionally bought
my strontium at www.amazon.com, I usually buy
it at www.iherb.com, which ranks its brands
by popularity within categories. For example, if you search “strontium,” the eight
products listed below will appear. I buy one of the number-2-ranked products,
AOR, Strontium Support II, 120 veggie-caps. Buying the larger bottle is cheaper
than buying the number-5-ranked 60-capsule bottle of the same product. Buying
two or more bottles gives you quantity discounts at iHerb.
If you buy AOR products directly
from the manufacturer at www.aor.us, you can
use the code, aor25off,
for 25% off your entire order. This code will work until the end of 2018 and
can be used multiple times.
Nature's Life and AOR claim
to follow Good Manufacturing Practices (GMP). The GMP designation is very
important in assuring quality. Check with each manufacturer’s website for full
details.
Number
1 in Strontium
Life
Extension, Strontium Caps, Mineral for Bone Health, 750 mg, 90 vegetarian
capsules
750 mg strontium in three capsules, other ingredients: microcrystalline cellulose, vegetable stearate, silica, vegetable cellulose capsule
750 mg strontium in three capsules, other ingredients: microcrystalline cellulose, vegetable stearate, silica, vegetable cellulose capsule
Number
2 in Strontium (tied with Nature’s Life)
Advanced Orthomolecular Research AOR, Advanced Series, Strontium Support
II, 120 veggie-caps
682 mg strontium in two capsules, other ingredients: sodium stearyl fumarate, hypromellose capsule, Good Manufacturing Practices (GMP) manufacturing, independent testing, quality assured
Number 2 in strontium (tied with AOR, Strontium Support II,
120 veggie-caps)
Nature’s Life, Strontium, 680 mg, 60 tablets
680 mg strontium in two tablets, other ingredients: cellulose,
silica, stearic acid, GMP manufacturing, quality assurance procedures
Number 4 in strontium
Best
Naturals, Strontium, 680 mg, 90 capsules
680
mg strontium in two capsules, other ingredients: gelatin
(capsule), rice powder, vegetable magnesium stearate, meets GMP
Number 5 in strontium (tied with Nature’s Life, Strontium
Plus D-3, 60 tablets)
Advanced Orthomolecular Research AOR,
Advanced Series, Strontium Support II, 60 veggie-caps
682
mg strontium in two capsules, other ingredients: sodium stearyl fumarate, hypromellose
capsule, meets Good Manufacturing Practices (GMP) manufacturing, independent
testing, quality assured
Number
5 in strontium (tied with AOR Strontium Support II, 60 veggie-caps)
Nature’s
Life, Strontium Plus D-3, 60 tablets
680 mg strontium and
400 IU D3 in two tablets, other ingredients: cellulose, stearic acid, magnesium
stearate and silica, meets Quality Assurance Procedures and Good Manufacturing
Practices
Number
7 in strontium
EuroPharma, Terry Naturally, Strontium, 60
capsules
680
mg strontium in two capsules, other ingredients: hydroxypropyl methylcellulose
(vegetable cellulose capsules), cellulose powder, vegetable source magnesium
stearate
Number
8 in strontium and number 62 in multimineral formulas
Onnit, Stron
Bone, 90 capsules
Wednesday, May 9, 2018
Quantitative Ultrasound as Alternative to DXA
Because BMD measured by DXA is prone to
overestimation when one is taking strontium, I look at the CHANGE in my DXA
score (at each site) from one scan to the next, not the absolute value. So far
(10 years on strontium), each scan has been progressively better than the
previous scan.
Another option for someone on strontium is to have a
quantitative ultrasound (QUS) to
assess bone health. QUS is not affected
by strontium content in bone. Another positive is that the procedure uses ultrasound
waves, not radiation.
https://www.ncbi.nlm.nih.gov/pubmed/29080282
https://www.ncbi.nlm.nih.gov/pubmed/29080282
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Wandering Skeleton
Artist: Joel Hoekstra
Osteoporotic Bone
Source: www.mayoclinic.com