Skeleton Pirate

Skeleton Pirate
Artist: LindaB

WELCOME TO STRONTIUM FOR BONES BLOG

Have you experienced negative, and even dangerous, side effects from Fosamax (alendronate), Boniva (ibandronate), Actonel (risedronate), Reclast (zoledronic acid), Prolia (denosumab), Forteo (teriparatide), Tymlos (abaloparatide), or other drugs prescribed for osteoporosis? If you have, then rest assured there is a safe, effective treatment for this condition. Strontium, primarily in the form of strontium citrate, is taken orally once a day.

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Blog Archive

Saturday, February 8, 2020

Calculating Body Frame Size

Having a small, thin frame is a risk factor for osteoporosis. So, how do you determine if you have a small, medium, or large frame? 

Overview

Body frame size is determined by a person's wrist circumference in relation to
his height. For example, a man whose height is over 5' 5" and wrist is 6"
would fall into the small-boned category.
Determining frame size: To determine the body frame size, measure the
wrist with a tape measure and use the following chart to determine whether
the person is small, medium, or large boned.
Women:
  • Height under 5'2" 
    • Small = wrist size less than 5.5"
    • Medium = wrist size 5.5" to 5.75"
    • Large = wrist size over 5.75" 
  • Height 5'2" to 5' 5" 
    • Small = wrist size less than 6"
    • Medium = wrist size 6" to 6.25"
    • Large = wrist size over 6.25" 
  • Height over 5' 5" 
    • Small = wrist size less than 6.25"
    • Medium = wrist size 6.25" to 6.5"
    • Large = wrist size over 6.5" 
Men:
  • Height over 5' 5" 
    • Small = wrist size 5.5" to 6.5"
    • Medium = wrist size 6.5" to 7.5"
    • Large = wrist size over 7.5" 

https://medlineplus.gov/ency/imagepages/17182.htm

Thursday, January 9, 2020

A Picture Is Worth a Thousand Words in Describing the Effects of Strontium on Bone

Micro computed tomography or "micro-CT" is x-ray imaging in 3D, by the same method used in hospital CT (or "CAT") scans, but on a small scale with massively increased resolution. It really represents 3D microscopy, where very fine scale internal structure of objects is imaged non-destructively.

“3D analysis of 3‐yr biopsies with treatment (20 biopsies) and placebo (21 biopsies) using μCT showed significant changes in microarchitecture with, in the strontium ranelate group, higher cortical thickness (+18%, p = 0.008) and trabecular number (+14%, p = 0.05), and lower structure model index (SMI) (−22%, p = 0.01) and trabecular separation (−16%, p = 0.04), with no change in cortical porosity. The changes in 3D microarchitecture may enhance bone biomechanical competence and explain the decreased fracture rate with strontium ranelate.”
“Postmenopausal osteoporosis is a chronic skeletal disorder involving compromised bone strength leading to an increased rate of fracture. Bone strength and therefore fracture risk depends on microarchitecture, matrix volume, and mineralization. Both cortical and trabecular bone are affected by the disease, with progressive considerable alterations in microarchitecture. The imbalance in bone remodeling in osteoporosis, in which bone formation is not able to compensate for bone resorption, leads to trabecular thinning and a loss of connectivity. As the disease progresses through years, continued increase remodeling rates lead to deep resorption cavities, the trabecular plates become perforated, and the connecting rods dissolve. As a consequence, there is a continuous shift from a plate‐like structure to a rod‐like structure. Simultaneously, in cortical bone, extensive remodeling at the endocortical surfaces “trabecularizes” (makes similar to trabecular bone) the inner part of cortical bone.” 
“Cortical bone is the major component of long bone, for example, in the femoral shaft, in which rigidity to withstand load and movement is favored over flexibility. On the other hand, bone with a large proportion of trabecular bone is lighter and more flexible and can absorb more energy, for example, in the vertebrae. Both types of bone are susceptible to osteoporotic fracture at rates dependent on a number of variables, including microarchitecture.”

“The 3D analysis from the μCT studies goes beyond the histomorphometric results by showing differences on the trabecular and cortical microarchitecture of bone in favor of strontium ranelate compared with placebo (Fig. 1). In trabecular bone, Tb.N (trabecular number) was higher and Tb.Sp (trabecular separation) was lower in the treated group, indicating a thickening of the trabecular elements. The 22% reduction in trabecular SMI toward a value closer to zero means that 3‐yr treatment has shifted the structure of the cancellous bone away from a rod‐like structure (SMI = 3) toward a normal structure based on plates (SMI = 0). The significant improvement in two of these parameters with strontium ranelate is in line with an overall improvement in bone strength with this agent.”

“An increase in porosity or thinning in cortical bone reduces the resistance of bone to the propagation of cracks, which is one of the underlying defects in osteoporosis. Our 3D results showed that strontium ranelate significantly increases Ct.Th (cortical thickness) but had no effect on Ct.Po (cortical porosity). The anabolic agent teriparatide may actually increase Ct.Po.





Figure 1. 3D microstructure from μCT of transiliac bone biopsies from postmenopausal osteoporotic 
women receiving strontium ranelate (2 g/d) or placebo for 3 yr.




Wandering Skeleton

Wandering Skeleton
Artist: Joel Hoekstra

Osteoporotic Bone

Osteoporotic Bone
Source: www.mayoclinic.com

How Strontium Builds Bones

Strontium is a mineral that tends to accumulate in bone. Studies have shown that oral doses of strontium are a safe and effective way to prevent and reverse osteoporosis. Doses of 680 mg per day appear to be optimal. See my "For More Information About Strontium" links section.

Osteoporosis is caused by changes in bone production. In healthy young bones there is a constant cycle of new bone growth and bone removal. With age, more bone is removed and less new bone is produced. The bones become less dense and thus more fragile.

Scientists believe that strontium works in two ways. It may stimulate the replication of pre-osteoblasts, leading to an increase in osteoblasts (cells that build bone). Strontium also directly inhibits the activity of osteoclasts (cells that break down bone). The result is stronger bones.

When taking strontium, be sure to take 1200 mg calcium, 1000 IU vitamin D3, and 500 mg magnesium daily. It is best to take strontium late at night on an empty stomach. Calcium and strontium may compete with each other for absorption if taken together.