Skeleton Pirate

Skeleton Pirate
Artist: LindaB


Have you experienced, or read about, negative, and even dangerous, side effects from Fosamax (alendronate), Boniva (ibandronate), Actonel (risedronate), and other bisphosphonates prescribed for osteoporosis? If you have, then rest assured there is a safe, effective treatment for this condition. Strontium, primarily in the form of strontium citrate, is taken orally once a day.

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Friday, March 13, 2015

Women's Mid-Life Non-Traumatic Fracture Risk Higher With Low Vitamin D

The lower a woman's vitamin D levels as she transitions to menopause, the greater her risk of sustaining a non-traumatic fracture. 

"Women who have levels less than 20 nanograms per milliliter would need some type of vitamin D supplementation," Dr. Jane A. Cauley of the University of Pittsburgh, who worked on the study, told Reuters Health. The findings back up the Institute of Medicine's conclusion that levels lower than 20 ng/ml are insufficient for skeletal health, she added.

Bone loss is known to accelerate during the menopausal transition, and postmenopausal women require significantly more calcium to reach neutral calcium balance than perimenopausal women, Dr. Cauley and her team note in their report, online February 23 in the Journal of Clinical Endocrinology and Metabolism.

To determine if serum 25(OH)D levels would be associated with changes in bone mineral density (BMD) and fracture risk, the researchers looked at data from the Study of Women's Health Across the Nation (SWAN) on 124 women with an incident traumatic fracture, 88 with an incident non-traumatic fracture, and 1,532 who did not sustain fractures during the study's average follow-up period of 9.5 years. 

Each woman had her serum 25(OH)D level checked at her third annual visit, while her BMD was assessed annually. The women's mean age at the study's outset was 48.5.

The study participants' mean 25(OH)D levels were 21.8 ng/ml, and 43% had levels below 20 ng/mL. While multivariate analysis found no association between 25(OH)D levels and traumatic fracture risk, the risk of non-traumatic fractures decreased by 28% for every 10 ng/ml increase in serum 25(OH)D. [Referring to Table 3 of the original article, “For every 10 ng/ml increase in 25(OH)D, the hazard ratio (HR) for nontraumatic fracture was 0.72 (0.54, 0.95).”; 1.00 minus 0.72 equals 0.28, or 28%]

Women with levels of 20 ng/ml or higher had a 46% lower risk of fracture during follow-up than women with lower levels of 25(OH)D. However, there was no association between baseline 25(OH)D and changes in BMD at the lumbar spine or femoral neck across menopause.

Roughly 22% of the women in the study had vitamin D levels greater than 30 ng/ml, Dr. Cauley said, so the study lacked power to determine if these women's non-traumatic fracture risk was further reduced.
"We didn't see any relationship between 25(OH)D and these bone changes, but we were somewhat limited in that we didn't have any information on how vitamin D changed across menopause," she added.

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Wandering Skeleton

Wandering Skeleton
Artist: Joel Hoekstra

Osteoporotic Bone

Osteoporotic Bone

How Strontium Builds Bones

Strontium is a mineral that tends to accumulate in bone. Studies have shown that oral doses of strontium are a safe and effective way to prevent and reverse osteoporosis. Doses of 680 mg per day appear to be optimal. See my "For More Information About Strontium" links section.

Osteoporosis is caused by changes in bone production. In healthy young bones there is a constant cycle of new bone growth and bone removal. With age, more bone is removed and less new bone is produced. The bones become less dense and thus more fragile.

Scientists believe that strontium works in two ways. It may stimulate the replication of pre-osteoblasts, leading to an increase in osteoblasts (cells that build bone). Strontium also directly inhibits the activity of osteoclasts (cells that break down bone). The result is stronger bones.

When taking strontium, be sure to take 1200 mg calcium, 1000 IU vitamin D3, and 500 mg magnesium daily. It is best to take strontium late at night on an empty stomach. Calcium and strontium may compete with each other for absorption if taken together.