Skeleton Pirate

Skeleton Pirate
Artist: LindaB

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Have you experienced, or read about, negative, and even dangerous, side effects from Fosamax (alendronate), Boniva (ibandronate), Actonel (risedronate), and other bisphosphonates prescribed for osteoporosis? If you have, then rest assured there is a safe, effective treatment for this condition. Strontium, primarily in the form of strontium citrate, is taken orally once a day.

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Monday, January 5, 2015

Salt and osteoporosis



Introduction

Osteoporosis is a condition involving the thinning of bones (bone demineralization), leaving them brittle and more susceptible to fracture. Ninety nice percent of calcium is stored in the bones, so sufficient calcium is important in order to maintain or reach peak bone mass (PBM).

In the UK, an estimated 3 million people are suffering from osteoporosis, with 1 in 2 women and 1 in 3 men over 50 years old breaking a bone at least once, mainly due to poor bone health. Each month, 1,150 people die as a result of a hip fracture. Osteoporosis mainly effects the older population, with 19.8 million people over the age of 50 in the UK. Since the 1960’s there has been a 7 fold increase in the number of osteoporosis cases. Each year osteoporosis costs the NHS approximately 2.3 billion pounds.

Who is most at risk of osteoporosis?

The older population are more at risk of osteoporosis because bones naturally become thinner as we get older. Post-menopausal women are particularly at risk of osteoporosis because of the decrease in the female hormone, estrogen. Those with higher salt intakes are increasing the amount of bone demineralization that takes place.

Studies have also demonstrated that there is a correlation between salt intake and calcium excretion in young and adolescent girls. It has been suggested that this may result in a reduced peak bone mass, which would increase the risk of osteoporosis later in life.  Consuming a low salt diet during adolescent years may therefore be important, to reduce the risk of osteoporosis later in life.

How does Salt Contribute?

Studies dating back to the 1980’s have found possible links between salt intake and urinary calcium (Ca) excretion.

Figure 1 – Changes in hip bone density with different urinary sodium excretions. 
A high salt intake increases calcium losses in the urine (calciuria), some of which will be directly from the bones. One study found that for each 100mmol increase in salt intake, urinary Ca is increased by 1.4mmol. If this loss is assumed to be from the bone, then this equates to about 1% extra loss of bone each year.   Over extended periods this would lead to the weakening of bones and ultimately osteoporosis.

Both epidemiological studies and randomized trials have shown that a decrease in salt intake reduces urinary calcium excretion. A study in post-menopausal women showed that the loss of hip bone density over 2 years was related to 24-hour urinary sodium at entry to the study, and was as strong as that relating to calcium intake. It was calculated that a reduction in salt intake from 10 to 5 g/day would have the same effect on hip bone density as an increase in calcium intake of 1000mg/day, a difficult amount to achieve without resorting to supplements (Fig 1).  Another study has suggested that in postmenopausal women with a sodium intake of more than or equal to 3.4g/day (8.5g salt), a reduction in salt intake would benefit their bone health.

Blood Pressure, Osteoporosis and Kidney Stones

Salt intake and blood pressure are strongly linked, and it is also believed that patients with high blood pressure excrete more calcium in the urine and are, therefore, at higher risk of osteoporosis and kidney stones.  Recently, a study showed sodium to be a major linking factor between blood pressure and osteoporosis. The authors found that hip and spine Bone Mass Density (BMD) were inversely correlated with a higher sodium excretion, i.e. the higher the salt intake, the lower the BMD. They concluded that the increase in calcium excretion is obligatory as a result of the increased sodium in the diet (Fig 2).  Another study showed that a 20mmHg increase in BP is associated with 0.28mmol/day increase in Urinary Ca.

Figure  2 – the link between salt intake, blood pressure and bone mineral loss.

Current Salt Intake & Dietary Advice

Almost everyone in the UK (and the rest of the Western world) eats too much salt. The daily recommended amount in the UK is no more than 6 grams a day; the current average salt intake is 8.6g salt a day although many people are eating more than this.

People with or considered at risk of osteoporosis should ensure that they keep their salt intake below the recommended maximum of 6g. This can be achieved by simple changes, such as consuming less processed foods and checking product labels before purchase. Consuming low salt dairy products such as milk will also help maintain bone mass. Caffeine and fizzy drinks are thought to reduce bone mass, and therefore should be kept to a minimum. An increase in Vitamin D, Zinc and Copper may also be of help.
The original article with references is available here: 

Also see my next post, "Americans Consume Too Much Sodium (Salt)," for information about salt intake in the U.S.A.  

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Wandering Skeleton

Wandering Skeleton
Artist: Joel Hoekstra

Osteoporotic Bone

Osteoporotic Bone
Source: www.mayoclinic.com

How Strontium Builds Bones

Strontium is a mineral that tends to accumulate in bone. Studies have shown that oral doses of strontium are a safe and effective way to prevent and reverse osteoporosis. Doses of 680 mg per day appear to be optimal. See my "For More Information About Strontium" links section.

Osteoporosis is caused by changes in bone production. In healthy young bones there is a constant cycle of new bone growth and bone removal. With age, more bone is removed and less new bone is produced. The bones become less dense and thus more fragile.

Scientists believe that strontium works in two ways. It may stimulate the replication of pre-osteoblasts, leading to an increase in osteoblasts (cells that build bone). Strontium also directly inhibits the activity of osteoclasts (cells that break down bone). The result is stronger bones.

When taking strontium, be sure to take 1200 mg calcium, 1000 IU vitamin D3, and 500 mg magnesium daily. It is best to take strontium late at night on an empty stomach. Calcium and strontium may compete with each other for absorption if taken together.