Skeleton Pirate

Skeleton Pirate
Artist: LindaB


Have you experienced, or read about, negative, and even dangerous, side effects from Fosamax (alendronate), Boniva (ibandronate), Actonel (risedronate), and other bisphosphonates prescribed for osteoporosis? If you have, then rest assured there is a safe, effective treatment for this condition. Strontium, primarily in the form of strontium citrate, is taken orally once a day.

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Friday, September 13, 2013

Protein Believed to Cause Postmenopausal Osteoporosis

Researchers have identified a protein that likely causes osteoporosis in women after menopause. In experiments on mice, the research team from Tokyo’s Keio University School of Medicine and other institutions found that a decrease in the secretion of estrogen enhances the function of HIF1 alpha protein. Once the amount of estrogen secreted by the ovaries begins to decline around the time of menopause, HIF1 alpha protein in osteoclasts increases.

Normal mice after menopause showed decreased femoral bone density compared with premenopausal levels, but mice whose genes were manipulated so as not to produce the HIF1 alpha protein did not show a decline of femoral bone density even after menopause. Moreover, a substance to inhibit the function of the HIF1 alpha protein that was given to postmenopausal mice led to an increase of bone density compared with premenopausal levels. The discovery is expected to lead to the development of an effective medicine to prevent osteoporosis.

The study is to be published in the online edition of the Proceedings of the U.S. National Academy of Science.



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Wandering Skeleton

Wandering Skeleton
Artist: Joel Hoekstra

Osteoporotic Bone

Osteoporotic Bone

How Strontium Builds Bones

Strontium is a mineral that tends to accumulate in bone. Studies have shown that oral doses of strontium are a safe and effective way to prevent and reverse osteoporosis. Doses of 680 mg per day appear to be optimal. See my "For More Information About Strontium" links section.

Osteoporosis is caused by changes in bone production. In healthy young bones there is a constant cycle of new bone growth and bone removal. With age, more bone is removed and less new bone is produced. The bones become less dense and thus more fragile.

Scientists believe that strontium works in two ways. It may stimulate the replication of pre-osteoblasts, leading to an increase in osteoblasts (cells that build bone). Strontium also directly inhibits the activity of osteoclasts (cells that break down bone). The result is stronger bones.

When taking strontium, be sure to take 1200 mg calcium, 1000 IU vitamin D3, and 500 mg magnesium daily. It is best to take strontium late at night on an empty stomach. Calcium and strontium may compete with each other for absorption if taken together.