Skeleton Pirate

Skeleton Pirate
Artist: LindaB


Have you experienced, or read about, negative, and even dangerous, side effects from Fosamax (alendronate), Boniva (ibandronate), Actonel (risedronate), and other bisphosphonates prescribed for osteoporosis? If you have, then rest assured there is a safe, effective treatment for this condition. Strontium, primarily in the form of strontium citrate, is taken orally once a day.

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Wednesday, September 23, 2009

Strontium Ranelate Safety

_ 3,790 patients were exposed to strontium ranelate during phase II and III trials. The overall incidence rates of adverse effects did not differ significantly from placebo. Adverse effects seen were generally mild and transient. The most common were:

_ headache (3.0% v 2.4%), nausea (6.6% v 4.3%), diarrhea (6.5% v 4.6%), loose stools (1.1% v 0.2%) dermatitis (2.1% v 1.6%) and eczema (1.5% v 1.2%)

_ In phase III studies, the annual incidence of venous thromboembolism (VTE) observed over 4 years was approximately 0.7%, with a relative risk of 1.42 (CI 1.02; 1.98, p=0.036) in strontium ranelate treated patients as compared to placebo treated patients. The cause of this finding is unknown. Strontium ranelate should be used with caution in patients at increased risk of VTE, including patients with a past history of VTE. The risk for strontium ranelate appears to be less than that seen with Selective Estrogen Receptor Modulator (SERM) or hormone replacement therapy (HRT).

_ Disturbances in consciousness, memory loss and seizures were all reported with higher frequency in the strontium ranelate group.

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Wandering Skeleton

Wandering Skeleton
Artist: Joel Hoekstra

Osteoporotic Bone

Osteoporotic Bone

How Strontium Builds Bones

Strontium is a mineral that tends to accumulate in bone. Studies have shown that oral doses of strontium are a safe and effective way to prevent and reverse osteoporosis. Doses of 680 mg per day appear to be optimal. See my "For More Information About Strontium" links section.

Osteoporosis is caused by changes in bone production. In healthy young bones there is a constant cycle of new bone growth and bone removal. With age, more bone is removed and less new bone is produced. The bones become less dense and thus more fragile.

Scientists believe that strontium works in two ways. It may stimulate the replication of pre-osteoblasts, leading to an increase in osteoblasts (cells that build bone). Strontium also directly inhibits the activity of osteoclasts (cells that break down bone). The result is stronger bones.

When taking strontium, be sure to take 1200 mg calcium, 1000 IU vitamin D3, and 500 mg magnesium daily. It is best to take strontium late at night on an empty stomach. Calcium and strontium may compete with each other for absorption if taken together.