FRAX®, launched by the
WHO Collaborating Centre for Metabolic Bone Diseases in 2008, calculates
the10-year probability of osteoporotic fracture based on clinical risk factors,
including bone mineral density (BMD) as an optional input.
A new feature of the online FRAX risk assessment tool
was launched in April 2014. The output of FRAX can now be adjusted for Trabecular
Bone Score (TBS™). Calculated by TBS iNsight™ software which installs on
existing DXA scanners, TBS is a simple method that estimates fracture risk
based on a determination of bone texture (an index correlated to bone
microarchitecture). The predictive ability of TBS is independent of FRAX
clinical risk factors and femoral neck bone mineral density (BMD) values. Educational
information and scientific publications about TBS are available at www.medimapsgroup.com.
By adding the patient’s TBS value
after the FRAX calculation, users will get a 10-year probability of risk of hip
fracture and major osteoporotic fracture adjusted for TBS. Clinical
advantages of using TBS-adjusted FRAX scores include:
- Increased accuracy of fracture prediction in the individual
- Reclassification of patients’ risk for future fracture above or below an intervention threshold
Following the calculation of FRAX
probabilities (at www.shef.ac.uk/FRAX)
the TBS value can be manually input by clicking on the TBS button below the
calculation results box. Entry of the TBS value, automatically calculated by
TBS iNsight™ V.3.0, if installed on your densitometer, produces a ‘FRAX
Adjusted for TBS’ score.”
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