http://www.ncbi.nlm.nih.gov/pubmed/24100401
Nat Rev Nephrol. 2013 Nov;9(11):681-92. doi: 10.1038/nrneph.2013.182. Epub 2013 Oct 8.
Patients with chronic kidney disease (CKD) have a high risk of bone
fracture owing to their low bone mineral density, which resembles that
of postmenopausal osteoporosis. However, the mineral and bone disorder
associated with CKD (CKD-MBD) is more complex than osteoporosis and the
same treatments might not be appropriate. In particular, vascular
calcifications are strongly associated with CKD-MBD, and must be taken
into consideration. Post hoc analyses of data from pivotal osteoporosis
studies suggest that in patients with mild stage 3 CKD and normal
parathyroid hormone (PTH), calcium and phosphate measurements,
conventional medications for osteoporosis (such as raloxifene,
bisphosphonates, teriparatide and denosumab) are effective at reducing
fracture rates. However, for patients with stage 4-5 CKD, or those with
abnormal PTH and mineral values, the available data are insufficient to
determine whether these commonly used medications are effective against
fractures. Moreover, all medications used to treat osteoporosis have
known or potential adverse effects in patients with CKD. Medicines that
increase bone formation by upregulating Wnt signalling have shown
promise in patients with osteoporosis and might be used to treat CKD-MBD
in the future, but off-target effects could limit their use in in this
setting.
Skeleton Pirate
WELCOME TO STRONTIUM FOR BONES BLOG
Have you experienced negative, and even dangerous, side effects from Fosamax (alendronate), Boniva (ibandronate), Actonel (risedronate), Reclast (zoledronic acid), Prolia (denosumab), Forteo (teriparatide), Tymlos (abaloparatide), or other drugs prescribed for osteoporosis? If you have, then rest assured there is a safe, effective treatment for this condition. Strontium, primarily in the form of strontium citrate, is taken orally once a day.
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Browse the posts and visit the link library of references.
Visitors to my blog can leave comments or ask questions and can remain anonymous, if they wish. Their comments are relayed to my g-mail inbox. Below each post, the number of comments for that post is cited and underlined because it is a link. By clicking on that link below any post, a window opens so that a visitor can leave a comment. Ideally, visitors leave comments on posts most relevant to their comments. All comments to my posts are moderated by me.
Browse the posts and visit the link library of references.
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September
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- Strontium Products, Inert Ingredients, and Dosages
- Long-Term Effect of Strontium Ranelate Treatment o...
- Strontium Succinate
- Strontium Offers Natural Osteoporosis Treatment Br...
- Vitamin D and Mortality Risk: Should Clinical Prac...
- The Meeks Method
- Recommended Amounts of Strontium and Calcium
- Therapy for Patients with CKD and Low Bone Mineral...
- Chronic Kidney Disease and Osteoporosis
- Strontium and Renal Impairment
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Thursday, September 4, 2014
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Wandering Skeleton
Osteoporotic Bone
How Strontium Builds Bones
Strontium is a mineral that tends to accumulate in bone. Studies have shown that oral doses of strontium are a safe and effective way to prevent and reverse osteoporosis. Doses of 680 mg per day appear to be optimal. See my "For More Information About Strontium" links section.
Osteoporosis is caused by changes in bone production. In healthy young bones there is a constant cycle of new bone growth and bone removal. With age, more bone is removed and less new bone is produced. The bones become less dense and thus more fragile.
Scientists believe that strontium works in two ways. It may stimulate the replication of pre-osteoblasts, leading to an increase in osteoblasts (cells that build bone). Strontium also directly inhibits the activity of osteoclasts (cells that break down bone). The result is stronger bones.
When taking strontium, be sure to take 1200 mg calcium, 1000 IU vitamin D3, and 500 mg magnesium daily. It is best to take strontium late at night on an empty stomach. Calcium and strontium may compete with each other for absorption if taken together.
Osteoporosis is caused by changes in bone production. In healthy young bones there is a constant cycle of new bone growth and bone removal. With age, more bone is removed and less new bone is produced. The bones become less dense and thus more fragile.
Scientists believe that strontium works in two ways. It may stimulate the replication of pre-osteoblasts, leading to an increase in osteoblasts (cells that build bone). Strontium also directly inhibits the activity of osteoclasts (cells that break down bone). The result is stronger bones.
When taking strontium, be sure to take 1200 mg calcium, 1000 IU vitamin D3, and 500 mg magnesium daily. It is best to take strontium late at night on an empty stomach. Calcium and strontium may compete with each other for absorption if taken together.
For More Information about Strontium
- A Dose-response Study With Strontium Malonate
- A Review of the latest insights into the mechanism of action of strontium in bone
- Antifracture Efficacy Over 10 Years With Strontium Ranelate
- Combination of Micronutrients for Bone (COMB) Study: Bone Density after Micronutrient Intervention
- Echolight REMS Scan of Young, Normal Female
- Effect of bone strontium on BMD measurements
- Effect of Lumbar Scoliosis on DXA Results
- Effects of SrR on Calcium Metabolism
- Effects of strontium ions on growth and dissolution of hydroxyapatite and on bone mineral detection
- Influence of strontium on bone mineral density and bone mineral content measurements by dual X-ray absorptiometry
- Interpretation of BMD Scans in Patients Stopping Strontium
- Melatonin-micronutrients Osteopenia Treatment Study (MOTS)
- National Osteoporosis Foundation
- Osteoporosis And Bone Physiology
- Post-Marketing Assessment of the Safety of Strontium Ranelate
- PubMed Abstract On The SOTI Study
- PubMed Abstract On The TROPOS Study
- Strontium ranelate Aristo
- Strontium Ranelate For Spinal Osteoarthritis
- Strontium: Breakthrough Against Osteoporosis
- Summary Safety Review - Strontium
- The Influence of Strontium on Bone Tissue Metabolism and Its Application in Osteoporosis Treatment
- Thirteen Key Diagnostic Tests
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