Skeleton Pirate

Skeleton Pirate
Artist: LindaB

WELCOME TO STRONTIUM FOR BONES BLOG

Have you experienced negative, and even dangerous, side effects from Fosamax (alendronate), Boniva (ibandronate), Actonel (risedronate), Reclast (zoledronic acid), Prolia (denosumab), Forteo (teriparatide), Tymlos (abaloparatide), or other drugs prescribed for osteoporosis? If you have, then rest assured there is a safe, effective treatment for this condition. Strontium, primarily in the form of strontium citrate, is taken orally once a day.

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Blog Archive

Monday, December 30, 2019

Strontium Folate for Bone Regeneration

Bone fractures and skeletal defects are rising worldwide and require new developments in bone regeneration. Strontium (Sr) is an element that has been investigated for its role in bone remodeling and bone formation. This study is a review of strontium folate (SrFO), a recently developed, non-protein based, bone-promoting agent that is of interest in medical and pharmaceutical fields due to its improved features compared to current therapies for bone diseases.

An aging population has led to a steady increase in the number of musculoskeletal conditions and, in particular, of cartilage and bone surgical procedures. Therefore, the development of alternative materials and strategies in bone replacement therapies is of interest. Above a critical size, bone defects are not repaired by the self-healing system of the tissue. Thus, an osteoconductive and osteoinductive device (or scaffold) is usually required in order to regenerate the lost tissue. The scaffold must be composed of materials that stimulate and favor the formation of new bone tissue and must be structurally stable during the process of cell growth and expansion. In this regard, autografts are still considered the “gold standard.” However, they have many drawbacks, such as limited availability and morbidity of the donor site. Alternatively, a proper scaffold made of a given biomaterial would be desirable both to fill the defect and to act as a reservoir for growth factors and/or cells.

SrFO-based scaffolds increase bone regeneration in vivo. The Sr-based-systems seem to be a useful alternative for the regeneration of bone tissue in complicated defects. 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6539601/


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Wandering Skeleton

Wandering Skeleton
Artist: Joel Hoekstra

Osteoporotic Bone

Osteoporotic Bone
Source: www.mayoclinic.com

How Strontium Builds Bones

Strontium is a mineral that tends to accumulate in bone. Studies have shown that oral doses of strontium are a safe and effective way to prevent and reverse osteoporosis. Doses of 680 mg per day appear to be optimal. See my "For More Information About Strontium" links section.

Osteoporosis is caused by changes in bone production. In healthy young bones there is a constant cycle of new bone growth and bone removal. With age, more bone is removed and less new bone is produced. The bones become less dense and thus more fragile.

Scientists believe that strontium works in two ways. It may stimulate the replication of pre-osteoblasts, leading to an increase in osteoblasts (cells that build bone). Strontium also directly inhibits the activity of osteoclasts (cells that break down bone). The result is stronger bones.

When taking strontium, be sure to take 1200 mg calcium, 1000 IU vitamin D3, and 500 mg magnesium daily. It is best to take strontium late at night on an empty stomach. Calcium and strontium may compete with each other for absorption if taken together.