Bone Remodeling

Bone remodeling is the replacement of old bone tissue by new bone tissue. This process, which mainly occurs in the adult skeleton to maintain bone mass, involves the coupling of bone formation and bone resorption and consists of five phases:

1. Activation: preosteoclasts are stimulated and differentiate under the influence of cytokines and growth factors into mature active osteoclasts

2. Resorption: osteoclasts digest mineral matrix (old bone)

3. Reversal: end of resorption

4. Formation: osteoblasts synthesize new bone matrix

5. Quiescence: osteoblasts become resting bone lining cells on the newly formed bone surface

http://www.iofbonehealth.org/health-professionals/about-osteoporosis/basic-bone-biology.html

A Dose-Response Study With Strontium Malonate

Osteologix, Inc. is conducting a Phase II clinical trial with strontium malonate in postmenopausal women. The study's primary objective is to compare dose-response effect of three levels of strontium malonate to placebo on bone resorption quantified by S-CTX-1 following 12 weeks of treatment. The four parallel groups in this trial will take 750 mg strontium malonate, 1000 mg strontium malonate, 2000 mg strontium malonate, 2 grams Protelos (strontium ranelate), and placebo. For more details, visit http://clinicaltrials.gov/ct2/show/NCT00409032

Alternative Medicine For Osteoporosis

Strontium citrate is an excellent alternative medicine for osteoporosis treatment. Instead of poisoning your body with drugs such as Fosamax, take strontium, a naturally occurring mineral present in water, food, and the human skeleton in trace amounts. Studies show that strontium promotes bone formation and decreases bone resorption (loss), leading to higher bone density.