Jennings
et al reported analyses of female identical twins with different amino acid
intakes.
Twins
with higher intakes of alanine and glycine had higher BMD at the spine than
their co-twins, with within-pair differences in spine BMD of 0.012 g/cm2
and 0.014 g/cm2, respectively.
In cross-sectional
multivariable analyses of 3,160 females aged 18-79 years, a higher intake of
total protein was associated with higher BMD at the spine (quartile Q4 to
quartile Q1: 0.017 g/ cm2) and forearm (Q4 to Q1: 0.010 g/cm2.
Intake
of alanine, arginine, glutamic acid, leucine, lysine, and proline was
associated with higher BMD at the spine and forearm, with the strongest
association observed for leucine (Q4 to Q1: 0.024 g/cm2).
When
intakes were stratified by source, vegetable or animal, prevalence of osteoporosis
or osteopenia was 13% to 19% lower comparing extreme quartiles of vegetable
intake for five amino acids (not glutamic acid or proline).
Jennings
A, MacGregor A, Spector T, Cassidy A. Amino acid intakes are associated with
bone mineral density and prevalence of low bone mass in women: Evidence from
discordant monozygotic twins. J Bone Miner Res 2015; doi:10.1002/jbmr.2703.