Jennings
et al reported analyses of female identical twins with different amino acid
intakes.
Twins
with higher intakes of alanine and glycine had higher BMD at the spine than
their co-twins, with within-pair differences in spine BMD of 0.012 g/cm2
and 0.014 g/cm2, respectively.
In cross-sectional
multivariable analyses of 3,160 females aged 18-79 years, a higher intake of
total protein was associated with higher BMD at the spine (quartile Q4 to
quartile Q1: 0.017 g/ cm2) and forearm (Q4 to Q1: 0.010 g/cm2.
Intake
of alanine, arginine, glutamic acid, leucine, lysine, and proline was
associated with higher BMD at the spine and forearm, with the strongest
association observed for leucine (Q4 to Q1: 0.024 g/cm2).
When
intakes were stratified by source, vegetable or animal, prevalence of osteoporosis
or osteopenia was 13% to 19% lower comparing extreme quartiles of vegetable
intake for five amino acids (not glutamic acid or proline).
Jennings
A, MacGregor A, Spector T, Cassidy A. Amino acid intakes are associated with
bone mineral density and prevalence of low bone mass in women: Evidence from
discordant monozygotic twins. J Bone Miner Res 2015; doi:10.1002/jbmr.2703.
3 comments:
Hello, After much reading I am a little confused. I have been prescribed Stontium ranelate, but am reluctant to take it, mainly because of the aspartame and because it is synthetic.
Will the strontium citrate do the same job? All the reports I read about 'ranelate' are positive, hence the confusion. I just cant seem to get my head around it all :(
To: Anonymous of 11/11/2015
I believe strontium citrate will do the same job as strontium ranelate because it appears to be strontium that exerts most or all of the positive effect on bone.
“Studies to date have predominantly focused on strontium ranelate rather than the readily available strontium citrate supplement as used in this study [Combination of Micronutrients for Bone (COMB) Study]. The results of this study, however, demonstrate that the micronutrient combination including strontium citrate is at least as effective in BMD change as strontium ranelate with suggestion of preferred efficacy of the former therapy at improving femoral neck outcomes. Furthermore, the ranelic acid salt is a purely synthetic molecular compound, while citrate is naturally occurring. It appears to be the strontium portion of the molecules which exerts most or all of the positive effect on bone.”
http://strontiumforbones.blogspot.com/2014/12/strontium-citrate-and-strontium-ranelate.html
I have been taking strontium citrate (Doctor's Best Strontium Bone Maker, 1944 mg strontium citrate, 680 mg elemental strontium in two capsules) for almost eight years. My BMD has shown significant improvement with each subsequent DXA scan. I began with osteoporosis, was at the osteopenia stage more than two years ago,and am probably normal today. My next DXA scan will tell.
I have had none of the side effects associated with strontium ranelate. I had mild constipation at first but corrected the problem by increasing my fiber.
I wish you good health, whatever you desire to take. Let me know if you have further questions.
Thank you so much, I now understand - I have ordered the Dr's Best and that is what I shall take.
Have a blessed weekend - Catherine ♥
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