Ten female volunteers were recruited
to have their bone strontium (Sr) levels measured as they self-supplemented
with Sr supplements of their choice. Nine of the ten had been diagnosed with osteopenia
and/or osteoporosis. Non-invasive bone Sr measurements were performed using an in
vivo x-ray fluorescence (IVXRF) I-125 based system. Thirty minute
measurements were taken at the finger and ankle, representing primarily
cortical and trabecular bone, respectively.
Baseline readings, representing
natural bone Sr levels were acquired since all volunteers had no previous
intake of Sr based supplements or medications. Once Sr supplements were
started, a 24 hour reading was taken, followed by frequent measurements ranging
from weekly, biweekly to monthly. The longest volunteer participation was
1535 days (4.2 years).
The mean baseline Sr signal observed
for the group was 0.42 ± 0.13 and 0.39 ± 0.07 for the finger and ankle,
respectively. After 24 hours, the mean Sr signal rose to 1.43 ± 1.12 and
1.17 ± 0.51, for the finger and ankle, respectively, representing a
statistically significant increase. Bone Sr levels continued to increase
throughout the length of the study. However, the Sr signal varied widely
between the individuals. After three years, the highest Sr signal observed was
28.15 ± 0.86 for the finger and 26.47 ± 1.22 for the ankle in one volunteer
compared to 3.15 ± 0.15 and 4.46 ± 0.36, for the finger and ankle, respectively,
in another. Furthermore, while it was previously reported by our group, that
finger bone Sr levels may plateau within two years, these results suggest
otherwise, indicating that bone Sr levels will continue to rise at both bone
sites even after 4 years of Sr intake.
The most
important points of this study are as follows:
- The bone Sr signal varies widely between subjects but follows a similar pattern.
- Results suggest bone Sr levels won't plateau as long as one supplements with Sr.
- This diagnostic tool is satisfactory for monitoring bone Sr levels over time.
The original article was published
online in “Bone” on February 08, 2014.
http://www.thebonejournal.com/article/S8756-3282%2814%2900004-0/abstract
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