Several studies have shown that it is possible to slow biological aging by taking certain supplements. Strength-training exercises may also help.
One study gave participants 2000 IU/day of vitamin D and 1 g per day of omega-3s (330 mg EPA plus 660 mg DHA from marine algae) and asked them to follow an at-home, strength-training exercise program for 30 minutes 3X/week. To calculate biological ages, the team analysed five epigenetic ‘clocks’ in the blood samples. These clocks are biomarkers that measure DNA methylation — patterns of molecular tags on DNA — at specific sites in the genome. Methylation levels increase or decrease at particular sites in a relatively predictable manner with age.
Omega-3 alone slowed the DNAm clocks, PhenoAge, GrimAge2 and DunedinPACE, and all three treatments had additive benefits on PhenoAge.
https://www.nature.com/articles/s43587-024-00793-y
Another study showed that taking a daily multivitamin can slow signs of biological aging. Centrum Silver was used in the study. The supplement's anti-aging effect was greater in people who were already biologically older than their years.
https://www.nature.com/articles/s41591-026-04239-3 (original article)
https://www.nature.com/articles/d41586-026-00741-3 (summary article about the study)