Strontium For Bones: Theories on How Strontium Prevents Fractures

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Have you experienced negative, and even dangerous, side effects from Fosamax (alendronate), Boniva (ibandronate), Actonel (risedronate), Reclast (zoledronic acid), Prolia (denosumab), Forteo (teriparatide), Tymlos (abaloparatide), or other drugs prescribed for osteoporosis? If you have, then rest assured there is a safe, effective treatment for this condition. Strontium, primarily in the form of strontium citrate, is taken orally once a day.

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Tuesday, April 26, 2022

Theories on How Strontium Prevents Fractures

Physiochemical Mechanisms/Sacrificial Bonds
Physiochemical mechanisms describe "how Sr (strontium) is able to affect the intrinsic tissue quality of bone by directly incorporating into bone at multiple levels, including the organic matrix and the hydrated layer surrounding hydroxyapatite (HA) crystals, forming sacrificial bonds and stabilizing hydration shells."

Cellular Mechanisms/Ca-sensing Receptor (CaSR)
"The cellular mechanisms are centered mainly around the Ca-sensing receptor (CaSR) and its ability to mediate bone cell function and respond to Sr, providing evidence for the dual-acting mechanism."

"Osteoclast precursors and mature osteoclasts express the CaSR on their cell membrane..."

Enhanced Bone Microarchitecture
"Microarchitecture is an important aspect of bone strength and increased fracture risk in patients with osteoporosis is associated with trabecular thinning and increased cortical porosity."

"Clinical studies have shown SR treatment increased cortical thickness and trabecular number and decreased trabecular spacing from baseline, determined using high-resolution peripheral quantitative computed tomography (HR-pQCT)."

https://www.sciencedirect.com/science/article/pii/S2352187220300334

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How Strontium Builds Bones

Strontium is a mineral that tends to accumulate in bone. Studies have shown that oral doses of strontium are a safe and effective way to prevent and reverse osteoporosis. Doses of 680 mg per day appear to be optimal. See my "For More Information About Strontium" links section.

Osteoporosis is caused by changes in bone production. In healthy young bones there is a constant cycle of new bone growth and bone removal. With age, more bone is removed and less new bone is produced. The bones become less dense and thus more fragile.

Scientists believe that strontium works in two ways. It may stimulate the replication of pre-osteoblasts, leading to an increase in osteoblasts (cells that build bone). Strontium also directly inhibits the activity of osteoclasts (cells that break down bone). The result is stronger bones.

When taking strontium, be sure to take 1200 mg calcium, 1000 IU vitamin D3, and 500 mg magnesium daily. It is best to take strontium late at night on an empty stomach. Calcium and strontium may compete with each other for absorption if taken together.

Strontium For Bones

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Tuesday, April 26, 2022

Theories on How Strontium Prevents Fractures

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