Physiochemical Mechanisms/Sacrificial Bonds
Physiochemical mechanisms describe "how Sr (strontium) is able to affect the intrinsic tissue quality of bone by directly incorporating into bone at multiple levels, including the organic matrix and the hydrated layer surrounding hydroxyapatite (HA) crystals, forming sacrificial bonds and stabilizing hydration shells."
Cellular Mechanisms/Ca-sensing Receptor (CaSR)
"The cellular mechanisms are centered mainly around the Ca-sensing receptor (CaSR) and its ability to mediate bone cell function and respond to Sr, providing evidence for the dual-acting mechanism."
"Osteoclast precursors and mature osteoclasts express the CaSR on their cell membrane..."
Enhanced Bone Microarchitecture
"Microarchitecture is an important aspect of bone strength and increased fracture risk in patients with osteoporosis is associated with trabecular thinning and increased cortical porosity."
"Clinical studies have shown SR treatment increased cortical thickness and trabecular number and decreased trabecular spacing from baseline, determined using high-resolution peripheral quantitative computed tomography (HR-pQCT)."
https://www.sciencedirect.com/science/article/pii/S2352187220300334
Skeleton Pirate
WELCOME TO STRONTIUM FOR BONES BLOG
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Browse the posts and visit the link library of references.
Tuesday, April 26, 2022
Theories on How Strontium Prevents Fractures
Wednesday, April 13, 2022
Vegetable Magnesium Stearate in Strontium Citrate Products
Magnesium stearate, also known as vegetable stearate, is used as a "flow agent" in supplement tablets and capsules to prevent different supplement ingredients from sticking to each other and to the blending and punching equipment. The flow agent ensures a homogenous blend of ingredients and a consistent dosage in each and every capsule or tablet. It is a common ingredient in many supplements, including strontium citrate products. I have never had a problem with it, but some people might have.
"Magnesium stearate is generally safe to consume, but too much of it can have a laxative effect. In large amounts, it can irritate the mucus lining of the bowels. This may trigger a bowel movement or diarrhea."
"Allergic reactions to magnesium stearate are rare, but you should avoid it and talk to your doctor if it affects you."
https://www.webmd.com/vitamins-and-supplements/what-is-magnesium-stearate
Below is a list of strontium citrate products with and without magnesium stearate. It is not an exhaustive list. If your product is not listed here, check the label.
Strontium Citrate Products with Magnesium Stearate
Life Extension Strontium has microcrystalline cellulose, vegetable cellulose (capsule), vegetable stearate, and silica, in addition to strontium citrate.
Nova Nutritions Strontium Citrate has a gelatin capsule, rice powder, and vegetable magnesium stearate.
Vitacost Strontium has hydroxypropyl methylcellulose, microcrystalline cellulose, vegetable stearic acid and vegetable magnesium stearate in addition to strontium citrate.
Strontium Citrate Products without Magnesium Stearate but with Other Additives
Swanson Strontium Citrate has gelatin, rice flower, calcium laurate, and silica.
Pure Encapsulations Strontium (Citrate) has a vegetarian capsule (cellulose, water) and contains hypoallergenic plant fiber (cellulose) and ascorbyl palmitate.
Strontium Citrate Products with No Additives
AOR Strontium Support II, which I take, is in a capsule composed of hypromellose and purified water and contains no additives.
AlgaeCal Strontium Boost is in a vegetable cellulose (vegetarian capsule) and contains no additives.
Strontium Chloride
I just became aware of a strontium chloride product for bone health,
Eniva Strontium Mineral Liquid Concentrate. One fluid ounce (30 mL) contains 250 mg strontium. The ingredients are purified water, strontium (from strontium chloride), natural flavors, citric acid, sorbic and/or benzoic acid(s) [protects freshness], stevia leaf extract. A liquid may offer quicker absorption than tablets or capsules that must first dissolve in the digestive tract before being absorbed.
https://eniva.com/strontium-mineral-liquid-concentrate-32-oz/?sk...
Wandering Skeleton
Osteoporotic Bone
How Strontium Builds Bones
Osteoporosis is caused by changes in bone production. In healthy young bones there is a constant cycle of new bone growth and bone removal. With age, more bone is removed and less new bone is produced. The bones become less dense and thus more fragile.
Scientists believe that strontium works in two ways. It may stimulate the replication of pre-osteoblasts, leading to an increase in osteoblasts (cells that build bone). Strontium also directly inhibits the activity of osteoclasts (cells that break down bone). The result is stronger bones.
When taking strontium, be sure to take 1200 mg calcium, 1000 IU vitamin D3, and 500 mg magnesium daily. It is best to take strontium late at night on an empty stomach. Calcium and strontium may compete with each other for absorption if taken together.
For More Information about Strontium
- A Dose-response Study With Strontium Malonate
- A Review of the latest insights into the mechanism of action of strontium in bone
- Antifracture Efficacy Over 10 Years With Strontium Ranelate
- Combination of Micronutrients for Bone (COMB) Study: Bone Density after Micronutrient Intervention
- Echolight REMS Scan of Young, Normal Female
- Effect of bone strontium on BMD measurements
- Effect of Lumbar Scoliosis on DXA Results
- Effects of SrR on Calcium Metabolism
- Effects of strontium ions on growth and dissolution of hydroxyapatite and on bone mineral detection
- Influence of strontium on bone mineral density and bone mineral content measurements by dual X-ray absorptiometry
- Interpretation of BMD Scans in Patients Stopping Strontium
- Melatonin-micronutrients Osteopenia Treatment Study (MOTS)
- National Osteoporosis Foundation
- Osteoporosis And Bone Physiology
- Post-Marketing Assessment of the Safety of Strontium Ranelate
- PubMed Abstract On The SOTI Study
- PubMed Abstract On The TROPOS Study
- Strontium ranelate Aristo
- Strontium Ranelate For Spinal Osteoarthritis
- Strontium: Breakthrough Against Osteoporosis
- Summary Safety Review - Strontium
- The Influence of Strontium on Bone Tissue Metabolism and Its Application in Osteoporosis Treatment
- Thirteen Key Diagnostic Tests