Although all postmenopausal women are estrogen deficient, women who have postmenopausal osteoporosis may have a defect, in addition to estrogen deficiency, that accounts for their higher rates of bone resorption and greater bone loss, relative to those who do not. To test the hypothesis that one defect is an impairment in renal calcium conservation, we measured renal calcium transport in 19 osteoporotic and 19 normal postmenopausal women, whose ages were 70 yr (range, 67–72) and 72 yr (range, 69–74), respectively. There was no difference between groups in values for serum ionized calcium and PTH concentrations or in renal filtered load of calcium. However, before PTH infusion, the osteoporotic women had lower values for tubular reabsorption of calcium (TRCa) of 96.8% vs. 98.0% and higher urinary calcium excretion of 0.194 mg/dL of glomerular filtrate (GF) vs. 0.125 mg/dL of GF than the normal women. After infusion of 200 U of synthetic PTH, TRCa increased and calcium excretion decreased comparably in both groups, so that the differences between groups after intervention remained: for TRCa, 98.3% vs.98.9%; and for calcium excretion, 0.099 mg/dL of GF vs. 0.066 mg/dL of GF. In conclusion, postmenopausal women with osteoporosis have a PTH-independent defect in renal calcium conservation. This defect is of sufficient magnitude to contribute to the greater negative calcium balance in postmenopausal women with osteoporosis vs. their postmenopausal peers.
https://academic.oup.com/jcem/article/83/6/1916/2865261
2 comments:
Vitamin D 1000 IU is a steroid vitamin, a group of fat-soluble pro-hormones that are best known for the role they play in supporting bone health and aiding in the absorption of calcium and phosphate from the gastrointestinal tract. However, a growing body of research highlights its important role in supporting other body systems, including cardiovascular and blood sugar balance as well as increasing musculoskeletal strength, neurological and immune function enabled by its ability to target over 200 different genes throughout the body.
To: Harbor compounding pharmacy
Yes, vitamin D maintains bone health and increases calcium absorption, in addition to several other functions. Ortho Molecular Products is a good brand, but there are other excellent brands of vitamin D3 that are far less expensive. I use Nature Made D3, which is USP certified, and costs less than half.
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