Skeleton Pirate

Skeleton Pirate
Artist: LindaB

WELCOME TO STRONTIUM FOR BONES BLOG

Have you experienced negative, and even dangerous, side effects from Fosamax (alendronate), Boniva (ibandronate), Actonel (risedronate), Reclast (zoledronic acid), Prolia (denosumab), Forteo (teriparatide), Tymlos (abaloparatide), or other drugs prescribed for osteoporosis? If you have, then rest assured there is a safe, effective treatment for this condition. Strontium, primarily in the form of strontium citrate, is taken orally once a day.

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Tuesday, January 14, 2014

What’s Behind the EMA’s Possible Suspension of Strontium Ranelate?


Here’s the official explanation:

"The EMA’s recommendations are based on an analysis of pooled data from randomized studies in about 7,500 post-menopausal women with osteoporosis. The results showed an increase in the risk of heart attack with Protelos/Osseor as compared with placebo (1.7% versus 1.1 %), with a relative risk of 1.6 (95% confidence interval, 1.07 to 2.38). There was also an imbalance in the number of serious heart events seen with the medicine in two other studies, one in men with osteoporosis and another in patients with osteoarthritis. No increased risk in mortality was observed."

http://www.ema.europa.eu/ema/index.jsp?curl=pages/news_and_events/news/2013/04/news_detail_001774.jsp&mid=WC0b01ac058004d5c1

The increased risk of heart attacks did not show up in the clinical trials of strontium ranelate, but it did show up in this analysis of pooled dated from the trials. The results showed a relative risk of 1.6 for heart attacks for the group on Protelos/Osseor compared to placebo. That result means someone taking strontium ranelate has a 60 percent higher risk of heart attacks than someone not taking the drug. That is quite significant.

Another reason the European Medicines Agency is considering suspending strontium ranelate may be that the EMA is worried about the possibility of experiencing with strontium ranelate what the French experienced with Mediator, a drug manufactured by Servier, which also manufactures strontium ranelate. The Mediator scandal became one of France’s biggest medical scandals of recent years. French health experts now believe that Mediator, developed for treating overweight diabetics, could have killed between 500 and 2,000 people between 1976 and November 2009, when it was finally banned for causing heart valve problems and deaths. These numbers are disputed by Servier, which says there are only three documented cases where death can be clearly attributed to Mediator. In other cases, it says, aggravating factors were at work.

http://www.bbc.co.uk/news/world-europe-12155639

A final reason some believe is behind the EMA’s recommendations and possible suspension is simply costs. Strontium ranelate is much more expensive than alendronate (alendronic acid, generic Fosamax) for osteoporosis.

 
Posted by BoneLady at 11:38 AM
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Wandering Skeleton

Wandering Skeleton
Artist: Joel Hoekstra

Osteoporotic Bone

Osteoporotic Bone
Source: www.mayoclinic.com

How Strontium Builds Bones

Strontium is a mineral that tends to accumulate in bone. Studies have shown that oral doses of strontium are a safe and effective way to prevent and reverse osteoporosis. Doses of 680 mg per day appear to be optimal. See my "For More Information About Strontium" links section.

Osteoporosis is caused by changes in bone production. In healthy young bones there is a constant cycle of new bone growth and bone removal. With age, more bone is removed and less new bone is produced. The bones become less dense and thus more fragile.

Scientists believe that strontium works in two ways. It may stimulate the replication of pre-osteoblasts, leading to an increase in osteoblasts (cells that build bone). Strontium also directly inhibits the activity of osteoclasts (cells that break down bone). The result is stronger bones.

When taking strontium, be sure to take 1200 mg calcium, 1000 IU vitamin D3, and 500 mg magnesium daily. It is best to take strontium late at night on an empty stomach. Calcium and strontium may compete with each other for absorption if taken together.